| Project/Area Number |
20790823
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
NAKAGAWA Noboru Hyogo College of Medicine, 医学部, 助教 (90412014)
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| Research Collaborator |
YAMANISHI Kiyofumi 兵庫医科大学, 医学部, 教授 (10182586)
TSUDA Tatsuya 兵庫医科大学, 医学部, 助教 (80434942)
IMAI Yasutomo 兵庫医科大学, 医学部, 助教 (10529514)
ISHIKAWA Chika 兵庫医科大学, 大学院生
YAMAMOTO Masaaki 兵庫医科大学, 大学院生
KONISHI Hiroe 兵庫医科大学, 実験補助
SAKAGUCHI Yoshiko 兵庫医科大学, 実験補助
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | プロテアーゼ活性化受容体 / 角化細胞 / 皮膚炎 / サイトカイン / ケモカイン / 炎症性皮膚疾患 / 腫瘍壊死因子α / インターロイキン8 / インターロイキン17 / テトラサイクリン |
|---|
| Research Abstract |
An agonist peptide for protease-activated receptor 2 (PAR2) enhanced the IL-1ss- or TNF-α-induced production of CXCL8, which was markedly suppressed by tetracyclines in normal human epidermal keratinocytes (NHEK). The PAR2 agonist and IL-17 induced also CXCL1, which was significantly decreased by cyclosporine A, active forms of vitamin D_3 and corticosteroids. These results suggest that the activation of keratinocyte PAR2 is involved in the potentiation of pro-inflammatory reactions and this process is modulated by the drugs used for treatment of inflammatory skin disorders.
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