| Project/Area Number |
20790828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
ECHIZENYA Masaru Akita University, 医学部, 講師 (60420056)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 精神生理学 / 臨床 / 気分障害 / 断眠 / 生体リズム / 治療 / うつ病エピソード / 薬剤抵抗性 / 断眠療法 / 睡眠位相前進 / 高照度光療法 / HAM-D / VAS / SDS |
|---|
| Research Abstract |
Sleep deprivation induces a rapid amelioration of mood in about 60% of depressed patients. After the next night of sleep, however, most patients experience a relapse. Previous studies demonstrated that some interventions could prevent a relapse. In this study, we tried total sleep deprivation followed by sleep phase advance and bright light therapy to drug-resistant depression. Treatment effects were evaluated by HAM-D (17 items and 6 items), SDS, VAS and SF-36. Twelve depressive patients (Unipolar/Bipolar=9/3) were treated in this protocol. According to the results, significant improvements were observed in HAM-D (17 items and 6 items), SDS, VAS and SF-36. Combined treatments in this study can be expected as clinically beneficial because drug-resistant patients improved in several days.
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