| Project/Area Number |
20790830
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Chiba University |
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Principal Investigator |
DAISUKE Matsuzawa Chiba University, 大学院・医学研究院, 助教 (10447302)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 臨床精神分子遺伝学 / 強迫性障害 / 遺伝子 / SNP / グルタミン酸 / MRS |
|---|
| Research Abstract |
Obsessive-compulsive disorder (OCD) is characterized by the compulsive behaviors in order to reduce anxiety due to obsession. In this study, a role of glutamate on the pathogenesis of OCD was investigated by mainly from the genetic aspects. SLC1A1 and SLCA3, genes of glutamate transporter, were selected, and 7 polymorphisms were identified. Genotype frequencies of four of the polymorphisms were different between normal controls and OCD patients. In addition, serum BDNF level was significantly higher in OCD than in normal controls. Quantitative measurement of glutamate was performed by 1H-MRS, but further evaluation is needed.
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