| Project/Area Number |
20790840
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Okayama University |
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Principal Investigator |
TAKAKI Manabu Okayama University, 岡山大学病院, 助教 (60452570)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 統合失調症 / DISC-1 / カリリン / シナプス / セントロソーム / PCM-1 / BBS4 |
|---|
| Research Abstract |
Disrupted in Schizophrenia-1 (Disc-1) is a candidate gene of schizophrenia. Following to the development, Disc-1, dynein and BBS4, the binding protein of Disc-1 moved from centrosome to spine. On the other hand, r-tubulin and PCM-1 did not. Disc-1 regulates kalirin and maintains spine. Disc-1 inhibited the binding of Kalirin-7 and Rac1. Clozapine, one of the atypical psychotics, which is effective to intractable schizophrenia and related to NMDA receptor function, increased PSD95, a post synaptic marker.
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