Brain imaging study of cognitive disorder mechanism and cognitive behavioral therapy in depression

• Project/Area Number: 20790843
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: ONODA Keiichi Hiroshima University, 医学部, 助教 (60432712)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: うつ病 / fMRI / 認知行動療法 / 脳機能画像 / 前頭前野 / 前帯状回

Research Abstract

It is well known that depressive patients tend to think negatively. Beck suggested a cognitive theory of depression, which the nature was cognitive impairments. In the current study using functional magnetic resonance imaging (fMRI) under emotional tasks, we have investigated the neurophysiological basis of the cognition, relationship between the cognitive impairment of depression and brain function, and objective/quantitative evaluation of cognitive behavioral therapy effects.

Research Products

• [Journal Article] Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change : a resting state functional magnetic resonance imaging study. (2011)
  • Author(s): Kunisato Y
  • Journal Title: Neuroscience Research Volume: 69 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Post-stroke apathy and hypoperfusion in basal ganglia : SPECT study. (2011)
  • Author(s): Onoda K
  • Journal Title: Cerebrovascular Diseases Volume: 31 Pages: 6-11
  • Peer Reviewed
• [Journal Article] なぜ心が痛いのか-社会神経科学における排斥研究の現状- (2010)
  • Author(s): 小野田慶一
  • Journal Title: 生理心理学と精神生理学 28(1) Pages: 29-44
• [Journal Article] Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity. (2010)
  • Author(s): Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Ueda, K., Suzuki, S., et al.
  • Journal Title: J Affect Disord 122 Pages: 76-85
• [Journal Article] Feedback-related negativity is correlated with unplanned impulsivity. (2010)
  • Author(s): Onoda K
  • Journal Title: Neuroreport Volume: 21 Pages: 736-739
  • Peer Reviewed
• [Journal Article] Brain activation during the perception of distorted body images in eating disorders. (2010)
  • Author(s): Miyake Y
  • Journal Title: Psychiatry Research Volume: 21 Pages: 183-192
  • Peer Reviewed
• [Journal Article] Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism. (2010)
  • Author(s): Onoda K
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: 5 Pages: 385-391
  • Peer Reviewed
• [Journal Article] Identification of rat P3-like processes in the anterior cingulate cortex and hippocampus. (2010)
  • Author(s): Hattori M.
  • Journal Title: Neuroscience Letter Volume: 472 Pages: 385-391
  • Peer Reviewed
• [Journal Article] Neural processing of negative word stimuli concerning body image in patients with eating disorders : An fMRI study. (2010)
  • Author(s): Miyake Y
  • Journal Title: Neuroimage Volume: 20 Pages: 1333-1339
  • Peer Reviewed
• [Journal Article] Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala : An fMRI study. (2010)
  • Author(s): Yoshino A
  • Journal Title: Neuroimage Volume: 50 Pages: 1194-1201
  • Peer Reviewed
• [Journal Article] Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity. (2010)
  • Author(s): Yoshimura S
  • Journal Title: Journal of Affective Disorder Volume: 122 Pages: 76-85
  • Peer Reviewed
• [Journal Article] なぜ心が痛いのか-社会神経科学における排斥研究の現状- (2010)
  • Author(s): 小野田慶一
  • Journal Title: 生理心理学と精神生理学 Volume: 28 Pages: 29-44
  • Peer Reviewed
• [Journal Article] Decreased ventral anterior cingulate cortex activity is associated with reduced social pain during emotional support. (2009)
  • Author(s): Onoda, K., Okamoto, Y., Nakashima, K., Nittono, H., Ura, M., Yamawaki, S.
  • Journal Title: Soc Neurosci 4 Pages: 443-454
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala. (2009)
  • Author(s): Yoshimura, S., Ueda, K., Suzuki, S., Onoda, K., Okamoto, Y., Yamawaki, S.
  • Journal Title: Brain Cogn 69 Pages: 218-225
• [Journal Article] Neural correlates of associative memory : the effects of negative emotion. (2009)
  • Author(s): Onoda, K., Okamoto, Y., Yamawaki, S.
  • Journal Title: Neurosci Res 64 Pages: 50-55
  • NAID: 120001700472
• [Journal Article] Decreased ventral anterior cingulate cortex activity is associated with reduced social pain during emotional support. (2009)
  • Author(s): Onoda K
  • Journal Title: Social Neuroscience 4(5) Pages: 443-454
  • Peer Reviewed
• [Journal Article] Neural correlates of associative memory : the effects of negative emotion. (2009)
  • Author(s): Onoda K
  • Journal Title: Neuroscience Research 64(1) Pages: 50-55
  • NAID: 120001700472
  • Peer Reviewed
• [Journal Article] Neural correlates of alexithymia in response to emotional stimuli : a study of anorexia nervosa patients. (2009)
  • Author(s): Miyake Y
  • Journal Title: Hiroshima Journal of Medical Science 58(1) Pages: 1-8
  • Peer Reviewed
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala. (2009)
  • Author(s): Yoshimura S
  • Journal Title: Brain and Cognition 69(1) Pages: 218-225
  • Peer Reviewed
• [Journal Article] 将来予期の神経メカニズムとうつ病に関する脳機能画像研究 (2009)
  • Author(s): 小野田慶一
  • Journal Title: 神経内科 71(2) Pages: 105-111
• [Journal Article] 遅延報酬選択における衝動性と抑うつ傾向 (2009)
  • Author(s): 小野田慶一
  • Journal Title: 脳と精神の医学 20(3) Pages: 249-254
  • NAID: 10028262508
  • Peer Reviewed
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala (2009)
  • Author(s): Shinpei Yoshimura
  • Journal Title: Brain & Cognition 69-1 Pages: 218-225
  • Peer Reviewed
• [Journal Article] 情動予期の神経基盤に関するfMRI研究 (2008)
  • Author(s): 小野田慶一・岡本泰昌・国里愛彦・山脇成人
  • Journal Title: 生理心理学と精神生理学 26(3) Pages: 229-235
  • NAID: 130004715505
• [Journal Article] Anterior cingulate cortex modulates preparatory activation during certain anticipation of negative picture. (2008)
  • Author(s): Onoda, K., Okamoto, Y., Toki, S., Ueda, K., Shishida, K., Kinoshita, A., et al.
  • Journal Title: Neuropsychologia 46 Pages: 102-110
• [Journal Article] Anterior cingulate cortex modulates preparatory activation during certain anticipation of negative picture (2008)
  • Author(s): Keiichi Onoda
  • Journal Title: Neuropsychologia 46-1 Pages: 102-110
  • Peer Reviewed
• [Journal Article] ストレス適応の神経生理学的基盤 (2008)
  • Author(s): 岡本泰昌
  • Journal Title: 日本薬理学雑誌 131-1 Pages: 5-10
• [Journal Article] ストレス制御に関する認知神経科学的研究 (2008)
  • Author(s): 小野田慶一
  • Journal Title: ストレス科学 23-3 Pages: 193-200
• [Journal Article] Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism.
  • Author(s): Onoda, K., Okamoto, Y., Nakashima, K., Nittono, H., Yoshimura, S., Yamawaki, S., Yamaguchi, S., Ura, M.
  • Journal Title: Soc Cogn Affect Neurosci. in press
• [Journal Article] Brain activation during the perception of distorted body images in eating disorders.
  • Author(s): Miyake Y
  • Journal Title: Psychiatry Research (印刷中)
  • Peer Reviewed
• [Journal Article] Does low self-esteem enhance social pain? The relationship between trait self-esteem and anterior cingulate cortex activation induced by ostracism.
  • Author(s): Onoda K
  • Journal Title: Social Cognitive and Affective Neuroscience (印刷中)
  • Peer Reviewed
• [Journal Article] Identification of rat P3-like processes in the anterior cingulate cortex and hippocampus.
  • Author(s): Hattori M.
  • Journal Title: Neuroscience Letter (印刷中)
  • Peer Reviewed
• [Journal Article] Neural processing of negative word stimuli concerning body image in patients with eating disorders : An fMRI study.
  • Author(s): Miyake Y
  • Journal Title: Neuroimage (印刷中)
  • Peer Reviewed
• [Journal Article] Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala : An fMRI study.
  • Author(s): Yoshino A
  • Journal Title: Neuroimage (印刷中)
  • Peer Reviewed
• [Journal Article] Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity.
  • Author(s): Yoshimura S
  • Journal Title: Neuroimage (印刷中)
  • Peer Reviewed
• [Journal Article] Neural correlates of associative memory : The effects of negative emotion
  • Author(s): Keiichi Onoda
  • Journal Title: Neuroscience Research (In press)
  • NAID: 120001700472
  • Peer Reviewed
• [Journal Article] 情動予期の神経基盤に関するfMRI研究
  • Author(s): 小野田慶一
  • Journal Title: 生理心理学と精神生理学 (印刷中)
  • NAID: 130004715505
  • Peer Reviewed
• [Presentation] Feedback-related negativity is correlated with unplanned impulsivity (2010)
  • Author(s): Onoda K
  • Organizer: International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 2010-11-01
• [Presentation] セロトニン欠乏による安静時脳機能ネットワークの変化 (2010)
  • Author(s): 小野田慶一
  • Organizer: 脳循環代謝学会
  • Place of Presentation: 大阪
• [Presentation] Feedback-related negativity is correlated with unplanned impulsivity. (2010)
  • Author(s): Onoda K., et al.
  • Organizer: International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
• [Presentation] フィードバック関連陰性電位は無計画的な衝動性と関連する (2010)
  • Author(s): 小野田慶一
  • Organizer: 認知神経科学会
  • Place of Presentation: 松江
• [Presentation] 衝動性とフィードバック関連陰性電位の関連 (2010)
  • Author(s): 小野田慶一
  • Organizer: 日本生理心理学会
  • Place of Presentation: 茨城
• [Presentation] Emotional support reduces social pain and anterior cingulate cortex activation during ostracism. (2010)
  • Author(s): Onoda K., et al.
  • Organizer: International Congress of Psychology
  • Place of Presentation: Berlin
• [Presentation] High/low discounting rates in reward prediction are differentially involved in dorsal/ventral striatum. (2010)
  • Author(s): Onoda K., et al.
  • Organizer: International Society of Brain Electromagnetic Topography
  • Place of Presentation: Kyoto
• [Presentation] High/low discounting rates in reward prediction are differentially involved in dorsal/ventral striatum (2009)
  • Author(s): Onoda K
  • Organizer: International Society of Brain Electromagnetic Topography
  • Place of Presentation: Kyoto
  • Year and Date: 2009-09-30
• [Presentation] Electrophysiological dynamics of working memory in human brain (2009)
  • Author(s): Abe S
  • Organizer: International Society of Brain Electromagnetic Topography
  • Place of Presentation: Kyoto
  • Year and Date: 2009-09-30
• [Presentation] 報酬予測における割引率と線条体の活動領域の関連 (2009)
  • Author(s): 小野田慶一
  • Organizer: 日本認知神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-25
• [Presentation] 情動価を伴う将来予期の神経機序とうつ病における認知 (2009)
  • Author(s): 小野田慶一
  • Organizer: 日本生理心理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-17
• [Presentation] 自尊心の高低が排斥による社会的痛みと前帯状回の活動に及ぼす影響 (2009)
  • Author(s): 小野田慶一
  • Organizer: 日本臨床神経生理学会
  • Place of Presentation: 北九州
• [Presentation] 報酬予測における割引率と線条体の活動領域の関連 (2009)
  • Author(s): 小野田慶一
  • Organizer: 日本認知神経科学会
  • Place of Presentation: 東京
• [Presentation] 報酬価を伴う将来予期の神経機序とうつ病における認知 (2009)
  • Author(s): 小野田慶一
  • Organizer: 日本生理心理学会
  • Place of Presentation: 京都
• [Presentation] ストレス制御に関する認知神経科学的研究 (2008)
  • Author(s): 小野田慶一
  • Organizer: 第24回ストレス学会
  • Place of Presentation: 大阪市
  • Year and Date: 2008-10-31
• [Presentation] 情緒的サポートの神経基盤 : fMRIによる検討 (2008)
  • Author(s): 小野田慶一
  • Organizer: 第72回日本心理学会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-09-21
• [Presentation] Emotional support reduces social pain and anterior cingulate cortex activation during ostracism (2008)
  • Author(s): Keiichi Onoda
  • Organizer: The 29th International Congress of Psychology
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-07-23
• [Presentation] 情緒的サポートは社会的痛みと前帯状回の活動を低減させる (2008)
  • Author(s): 小野田慶一
  • Organizer: 第26回日本生理心理学会
  • Place of Presentation: 那覇市
  • Year and Date: 2008-07-06
• [Presentation] 脳からみた受容と排斥 : 情緒的サポートは心理的痛みと脳の情動反応を低減させる (2008)
  • Author(s): 小野田慶一
  • Organizer: 第55回日本グループダイナミクス学会
  • Place of Presentation: 東広島市
  • Year and Date: 2008-06-14
• [Presentation] 脳からみた受容と排斥:情緒的サポートは心理的痛みと脳の情動反応を低減させる (2008)
  • Author(s): 小野田慶一
  • Organizer: 日本グループダイナミクス学会
  • Place of Presentation: 広島
• [Presentation] 情緒的サポートは社会的痛みと前帯状回の活動を低減させる (2008)
  • Author(s): 小野田慶一
  • Organizer: 日本生理心理学会
  • Place of Presentation: 沖縄
• [Presentation] 情緒的サポートの神経基盤:fMRIによる検討 (2008)
  • Author(s): 小野田慶一
  • Organizer: 日本心理学会
  • Place of Presentation: 札幌
• [Presentation] ストレス制御に関する認知神経科学的研究 (2008)
  • Author(s): 小野田慶一
  • Organizer: 日本ストレス学会
  • Place of Presentation: 大阪
• [Remarks] ホームページ等