Mathematics and computational analysis of brain structural MRI and application to psychiatric diseases

• Project/Area Number: 20790846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: UENO Takefumi Kyushu University, 保健医療学部, 准教授 (00441668)
• Research Collaborator: KANBA Shigenobu 九州大学, 大学院・医学研究院・精神病態医学, 教授 (50195187) ; ONITSUKA Toshiaki 九州大学大学, 大学病院, 講師 (00398059) ; 古田 歩 , 前田眼科, 医師
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: MRI / 脳 / 数学 / 画像処理 / 統計 / 精神疾患 / 統合失調症 / 気分障害

Research Abstract

Recently brain imaging studies using magnetic resonance imaging (MRI) were often reported in the psychiatry research. This study was aimed to apply an mathematical theory to the brain imaging study to understand the structural brain anatomy in psychiatric patients more simply and more accurately. We used differential geometry theories to segment the brain anatomical structure. Computational programs were written using differential geometry. Then we collected MRI imaging in psychiatric patients i.e. schizophrenia affective disorder and seizure. Using differential geometry method we compared intracranial volumes. However significant difference were not detected so far. By collecting MRI images and detecting the differences we can try to cutting edge of the psychiatric disorders in the future.

Research Products

• [Journal Article] Developmental changes in multivariate neuroanatomical patterns that predict risk for psychosis in 22q11.2 deletion syndrome (2011)
  • Author(s): Gothelf D, Hoeft F, Ueno T, Sugiura L, Lee AD, Thompson P, Reiss AL.
  • Journal Title: J Psychiatr Res. Volume: 45(3) Pages: 322-31
  • Peer Reviewed
• [Journal Article] Comparison between real sequential finger and imagery movements : an fMRI study revisited (2010)
  • Author(s): Takefumi Ueno, Masayuki Inoue, Kiichiro Morita, Toshihiko Matsuoka, Toshi Abe, Hisao Maeda
  • Journal Title: Brain Imaging and Behavior 4 Pages: 80-85
  • Peer Reviewed
• [Journal Article] Developmental changes in multivariate neuroanatomical patterns that predict risk for psychosis in 22q11.2 deletion syndrome. (2010)
  • Author(s): Gothelf D, Hoeft F, Ueno T, Sugiura L, Lee AD, Thompson P, Reiss AL.
  • Journal Title: Psychiatr Res.
  • Peer Reviewed
• [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : a MEG study. (2010)
  • Author(s): Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Kasai K, Ueno T, Kanba S
  • Journal Title: Bipolar Disord. 12 Pages: 804-812
  • Peer Reviewed
• [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds (2010)
  • Author(s): Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Kasai K, Ueno T, Kanba S
  • Journal Title: Bipolar Disord Volume: 12 Pages: 804-812
  • Peer Reviewed
• [Journal Article] Locked to the stimulation ; significance level of the phase locking factor (2009)
  • Author(s): Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
  • Journal Title: Proc.Cong.Image and Signal Processing IEEE 8 Pages: 4448-4451
  • Peer Reviewed
• [Journal Article] Locked to the stimulation ; significance level of the phase locking factor (2009)
  • Author(s): Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
  • Journal Title: Proc.Cong.Image and Signal Processing IEEE (8) Pages: 4448-51
  • Peer Reviewed
• [Journal Article] 精神疾患の神経生理学的研究 (2008)
  • Author(s): 鬼塚俊明、上野雄文
  • Journal Title: 臨床精神医学 37 Pages: 1277-80
• [Journal Article] 統合失調症の情動障害と扁桃核 (2008)
  • Author(s): 前田久雄、森田喜一郎、上野雄文
  • Journal Title: Clinical Neuroscience 26-4 Pages: 447-50
• [Journal Article] Brain Activities on fMRI Using the shiritori Task in Normal Subjects : Kurume
  • Author(s): Masayuki Inoue, Takefumi Ueno, Kiichiro Morita, Yoshihisa Shoji, Toshimasa Matsuoka, Ryo Fujiki, Toshi Abe, Naohisa Uchimura
  • Journal Title: Med J (in press)
  • Peer Reviewed
• [Presentation] Characteristics of the brain function related to a simple motor task in schizophrenia patients (2010)
  • Author(s): Ueno T, Inoue M, Fujiki R, Morita K
  • Organizer: Society for Nueroscience, Convention Center
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-14
• [Presentation] Characteristics of the brain function related to a simple motor task in schizophrenia patients (2010)
  • Author(s): Ueno T, Inoue M, Fujiki R, Morita K
  • Organizer: Society for Nueroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] Neural oscillationを指標とした双極性障害の脳機能研究 (2010)
  • Author(s): 織部直弥, 平野昭吾, 平野羊嗣, 上野雄文, 土本利架子, 中村一太, 小田祐子, 小原尚利, 前川敏彦, 大林長二, 神庭重信, 鬼塚俊明
  • Organizer: 第10回精神疾患と認知機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-13
• [Presentation] Difference between a real sequential finger and imagery movements : An fMRI study (2010)
  • Author(s): Ueno T., Inoue M., Morita K
  • Organizer: Human brain mapping
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-07
• [Presentation] Auditory sensory gating deficit to voices in psychotic bipolar disorder (2010)
  • Author(s): Hirano Y, Hirano S, Oribe N, Maekawa T, Tsunoda T, Nakamura I, Tsuchimoto R, Ueno T, Ninomiya H, Onitsuka T, Kanba S
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
• [Presentation] Locked to Stimulation : Significance Level of the Phase-Locking Factor (2009)
  • Author(s): Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
  • Organizer: 2nd International Congress on Image and Signal Processing
  • Place of Presentation: Saixiang Hotel, Tianjin, China
  • Year and Date: 2009-10-17
• [Presentation] A trial of skull stripping with intensity and mathamatical estimation (2009)
  • Author(s): T Ueno, R Fukushima, A Furuta, S Hirano, N Oribe, C Ohbayashi, Y Hirano, T Maekawa, R Tsuchimoto, S Kanba, T Onitsuka
  • Organizer: Annual Meeting of OHBM 2009, NeuroImage, Volume 47, Supplement 1, Pages S39-S41
  • Place of Presentation: Marriot Hotel, San Francisco
  • Year and Date: 2009-06-21
• [Presentation] A trial of skull stripping with intensity and mathamatical estimation (2009)
  • Author(s): T Ueno, R Fukushima, A Furuta, S Hirano, N Oribe, C Ohbayashi, Y Hirano, T Maekawa, R Tsuchimoto, S Kanba, T Onitsuka
  • Organizer: Annual Meeting of OHBM 2009
  • Place of Presentation: San Francisco
  • Year and Date: 2009-06-21
• [Presentation] VBMにおけるsmoothing kernelの違いについて (2009)
  • Author(s): 上野雄文
  • Organizer: MRIワーキンググループ
  • Place of Presentation: 東京大学、東京都
  • Year and Date: 2009-06-13
• [Presentation] VBMにおけるsmoothing kernelの違いについて (2009)
  • Author(s): 上野雄文
  • Organizer: MRIワーキンググループ
  • Place of Presentation: 東京
  • Year and Date: 2009-06-13
• [Presentation] 頭部MRI画像の組織分離の試み (2009)
  • Author(s): 上野雄文
  • Organizer: 生物学的精神医学会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2009-04-24
• [Presentation] 頭部MRI画像の組織分離の試み (2009)
  • Author(s): 上野雄文
  • Organizer: 生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-24
• [Presentation] 先端医学社 (2008)
  • Author(s): 上野雄文
  • Organizer: 分子精神医学 ; 精神疾患の画像研究 (分担)
  • Place of Presentation: 2
• [Book] 精神科医のための脳科学(機能的MRIと精神疾患、専門医のための精神科臨床リュミエール、16巻) (2010)
  • Author(s): 上野雄文
  • Publisher: 中山書店、東京都
• [Book] 機能的MRIと精神疾患、専門医のための精神科臨床リュミエール (2010)
  • Author(s): 上野雄文(共著)
  • Total Pages: 328
  • Publisher: 中山書店