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Mathematics and computational analysis of brain structural MRI and application to psychiatric diseases

Research Project

Project/Area Number 20790846
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

UENO Takefumi  Kyushu University, 保健医療学部, 准教授 (00441668)

Research Collaborator KANBA Shigenobu  九州大学, 大学院・医学研究院・精神病態医学, 教授 (50195187)
ONITSUKA Toshiaki  九州大学大学, 大学病院, 講師 (00398059)
古田 歩  , 前田眼科, 医師
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsMRI / 脳 / 数学 / 画像処理 / 統計 / 精神疾患 / 統合失調症 / 気分障害
Research Abstract

Recently brain imaging studies using magnetic resonance imaging (MRI) were often reported in the psychiatry research. This study was aimed to apply an mathematical theory to the brain imaging study to understand the structural brain anatomy in psychiatric patients more simply and more accurately. We used differential geometry theories to segment the brain anatomical structure. Computational programs were written using differential geometry. Then we collected MRI imaging in psychiatric patients i.e. schizophrenia affective disorder and seizure. Using differential geometry method we compared intracranial volumes. However significant difference were not detected so far. By collecting MRI images and detecting the differences we can try to cutting edge of the psychiatric disorders in the future.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Book (2 results)

  • [Journal Article] Developmental changes in multivariate neuroanatomical patterns that predict risk for psychosis in 22q11.2 deletion syndrome2011

    • Author(s)
      Gothelf D, Hoeft F, Ueno T, Sugiura L, Lee AD, Thompson P, Reiss AL.
    • Journal Title

      J Psychiatr Res.

      Volume: 45(3) Pages: 322-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between real sequential finger and imagery movements : an fMRI study revisited2010

    • Author(s)
      Takefumi Ueno, Masayuki Inoue, Kiichiro Morita, Toshihiko Matsuoka, Toshi Abe, Hisao Maeda
    • Journal Title

      Brain Imaging and Behavior 4

      Pages: 80-85

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental changes in multivariate neuroanatomical patterns that predict risk for psychosis in 22q11.2 deletion syndrome.2010

    • Author(s)
      Gothelf D, Hoeft F, Ueno T, Sugiura L, Lee AD, Thompson P, Reiss AL.
    • Journal Title

      Psychiatr Res.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : a MEG study.2010

    • Author(s)
      Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Kasai K, Ueno T, Kanba S
    • Journal Title

      Bipolar Disord. 12

      Pages: 804-812

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds2010

    • Author(s)
      Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Kasai K, Ueno T, Kanba S
    • Journal Title

      Bipolar Disord

      Volume: 12 Pages: 804-812

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locked to the stimulation ; significance level of the phase locking factor2009

    • Author(s)
      Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
    • Journal Title

      Proc.Cong.Image and Signal Processing IEEE 8

      Pages: 4448-4451

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Locked to the stimulation ; significance level of the phase locking factor2009

    • Author(s)
      Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
    • Journal Title

      Proc.Cong.Image and Signal Processing IEEE (8)

      Pages: 4448-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患の神経生理学的研究2008

    • Author(s)
      鬼塚俊明、上野雄文
    • Journal Title

      臨床精神医学 37

      Pages: 1277-80

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 統合失調症の情動障害と扁桃核2008

    • Author(s)
      前田久雄、森田喜一郎、上野雄文
    • Journal Title

      Clinical Neuroscience 26-4

      Pages: 447-50

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Brain Activities on fMRI Using the shiritori Task in Normal Subjects : Kurume

    • Author(s)
      Masayuki Inoue, Takefumi Ueno, Kiichiro Morita, Yoshihisa Shoji, Toshimasa Matsuoka, Ryo Fujiki, Toshi Abe, Naohisa Uchimura
    • Journal Title

      Med J (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Characteristics of the brain function related to a simple motor task in schizophrenia patients2010

    • Author(s)
      Ueno T, Inoue M, Fujiki R, Morita K
    • Organizer
      Society for Nueroscience, Convention Center
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Characteristics of the brain function related to a simple motor task in schizophrenia patients2010

    • Author(s)
      Ueno T, Inoue M, Fujiki R, Morita K
    • Organizer
      Society for Nueroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neural oscillationを指標とした双極性障害の脳機能研究2010

    • Author(s)
      織部直弥, 平野昭吾, 平野羊嗣, 上野雄文, 土本利架子, 中村一太, 小田祐子, 小原尚利, 前川敏彦, 大林長二, 神庭重信, 鬼塚俊明
    • Organizer
      第10回精神疾患と認知機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Difference between a real sequential finger and imagery movements : An fMRI study2010

    • Author(s)
      Ueno T., Inoue M., Morita K
    • Organizer
      Human brain mapping
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auditory sensory gating deficit to voices in psychotic bipolar disorder2010

    • Author(s)
      Hirano Y, Hirano S, Oribe N, Maekawa T, Tsunoda T, Nakamura I, Tsuchimoto R, Ueno T, Ninomiya H, Onitsuka T, Kanba S
    • Organizer
      29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Locked to Stimulation : Significance Level of the Phase-Locking Factor2009

    • Author(s)
      Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
    • Organizer
      2nd International Congress on Image and Signal Processing
    • Place of Presentation
      Saixiang Hotel, Tianjin, China
    • Year and Date
      2009-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] A trial of skull stripping with intensity and mathamatical estimation2009

    • Author(s)
      T Ueno, R Fukushima, A Furuta, S Hirano, N Oribe, C Ohbayashi, Y Hirano, T Maekawa, R Tsuchimoto, S Kanba, T Onitsuka
    • Organizer
      Annual Meeting of OHBM 2009, NeuroImage, Volume 47, Supplement 1, Pages S39-S41
    • Place of Presentation
      Marriot Hotel, San Francisco
    • Year and Date
      2009-06-21
    • Related Report
      2010 Final Research Report
  • [Presentation] A trial of skull stripping with intensity and mathamatical estimation2009

    • Author(s)
      T Ueno, R Fukushima, A Furuta, S Hirano, N Oribe, C Ohbayashi, Y Hirano, T Maekawa, R Tsuchimoto, S Kanba, T Onitsuka
    • Organizer
      Annual Meeting of OHBM 2009
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] VBMにおけるsmoothing kernelの違いについて2009

    • Author(s)
      上野雄文
    • Organizer
      MRIワーキンググループ
    • Place of Presentation
      東京大学、東京都
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] VBMにおけるsmoothing kernelの違いについて2009

    • Author(s)
      上野雄文
    • Organizer
      MRIワーキンググループ
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頭部MRI画像の組織分離の試み2009

    • Author(s)
      上野雄文
    • Organizer
      生物学的精神医学会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2009-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭部MRI画像の組織分離の試み2009

    • Author(s)
      上野雄文
    • Organizer
      生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 先端医学社2008

    • Author(s)
      上野雄文
    • Organizer
      分子精神医学 ; 精神疾患の画像研究 (分担)
    • Place of Presentation
      2
    • Related Report
      2008 Annual Research Report
  • [Book] 精神科医のための脳科学(機能的MRIと精神疾患、専門医のための精神科臨床リュミエール、16巻)2010

    • Author(s)
      上野雄文
    • Publisher
      中山書店、東京都
    • Related Report
      2010 Final Research Report
  • [Book] 機能的MRIと精神疾患、専門医のための精神科臨床リュミエール2010

    • Author(s)
      上野雄文(共著)
    • Total Pages
      328
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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