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Possibility of autologous cell transplantation therapy

Research Project

Project/Area Number 20790850
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionSapporo Medical University

Principal Investigator

ONO Takafumi  Sapporo Medical University, 医学部, 研究員 (50438024)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords精神薬理学 / 統合失調症 / 神経幹細胞 / 再生医療 / 細胞移植 / 神経保護 / 神経新生 / Poly I:C / 抗精神病薬 / Poly I : C
Research Abstract

We have suggested that the intravenous transplantation of neural stem cells could recover the negative symptom and cognitive dysfunction in the schizophrenic animal model. The exogenous neural stem cells have shown the neuroprotective effect and the promotive effect of neurogenesis, and the change of Akt and ERK activation may be concerned with the mechanism of the neuroprotective effect.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (9 results)

  • [Journal Article] 非定型抗精神病薬の神経新生作用2009

    • Author(s)
      橋本恵理, 鵜飼渉, 小野貴文, 齋藤利和
    • Journal Title

      脳21 12巻

      Pages: 95-199

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 気分障害における神経回路網の修復再生と認知機能2009

    • Author(s)
      鵜飼渉, 橋本恵理, 石井貴男, 吉永敏弘, 渡邊公彦, 小野貴文, 館農勝, 渡邉一平, 白坂智彦, 齋藤利和
    • Journal Title

      臨床精神医学 38巻

      Pages: 421-428

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 気分障害における神経回路綱の修復再生と認知機能2009

    • Author(s)
      鵜飼渉, 他
    • Journal Title

      臨床精神医学 38

      Pages: 421-428

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 非定型抗精神病薬の神経新生作用2009

    • Author(s)
      橋本恵理, 他
    • Journal Title

      脳21 12

      Pages: 195-199

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The common aspects of pathophysiology of alcoholism and depression2009

    • Author(s)
      Ukai Wataru, et al.
    • Journal Title

      日本アルコール・薬物医学会雑誌 44

      Pages: 704-711

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経新生と病態「向精神薬」2008

    • Author(s)
      橋本恵理
    • Journal Title

      臨床神経科学 26

      Pages: 887-889

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アルコールによる脳神経回路障害のメカニズムとその修復法の探索 : 神経細胞・神経幹細胞を用いたin vitro, in vivo解析2008

    • Author(s)
      鵜飼渉
    • Journal Title

      日本アルコール・薬物医学会雑誌 43

      Pages: 763-769

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アルコールによる脳障害とエピジェネティック制御機構2008

    • Author(s)
      石井貴男
    • Journal Title

      日本アルコール・薬物医学会雑誌 43

      Pages: 705-713

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of Yi-Gan San against beta amyloidinduced cyto toxicity on rat cortical neurons2008

    • Author(s)
      Tateno Masaru
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 32

      Pages: 1704-1707

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルコールによる脳神経回路網の異常 : 神経幹細胞を用いた修復の試み2008

    • Author(s)
      鵜飼渉
    • Journal Title

      日本神経精神薬理学雑誌 28

      Pages: 69-73

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation.

    • Author(s)
      Ono T, Hashimoto E, Ukai W, Ishii T, Saito T
    • Journal Title

      Schizophrenia Research (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Stem cell therapy as a new treatment strategy for schizophnia.2009

    • Author(s)
      Ukai W
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経幹細胞移植は統合失調症の慢性期症状を抑制する2009

    • Author(s)
      小野貴文
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経幹細胞移植は統合失調症の慢性期症状を抑制する2009

    • Author(s)
      小野貴文
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Altered trophic factor signaling in the mechanism of neuroprotection by exogenous neural stem cells.2008

    • Author(s)
      Ono T
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Altered trophic factor signaling in the mechanism of neuroprotection by exogenous neural stem cells2008

    • Author(s)
      Takafumi Ono
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] アルコール性精神障害に対する神経幹細胞移植療法の可能性に関する検討. 第20回日本アルコール精神医学会2008

    • Author(s)
      小野貴文
    • Organizer
      第11回ニコチン・薬物依存研究フォーラム平成20年度合同学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] アルコール性精神障害に対する神経幹細胞移植療法の可能性に関する検討2008

    • Author(s)
      小野貴文
    • Organizer
      第20回日本アルコール精神医学会第11回ニコチン・薬物依存研究フォーラム平成20年度合同学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] The effect of exogenous neural stem cell against the damaged neurons and neural stem cells.2008

    • Author(s)
      小野貴文
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] The effect of exogenous neural stem cell against the damaged neurons and neural stem cells2008

    • Author(s)
      小野貴文
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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