| Project/Area Number |
20790851
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
WATANABE Kimihiko Sapporo Medical University, 医学部, 研究員 (70464493)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳・神経 / 神経科学 / うつ病 / 血小板 / BDNF / 神経幹細胞 / 神経新生 / オーダーメイド治療 |
|---|
| Research Abstract |
Brain-derived neurotrophic factor (BDNF) exists in peripheral tissues and is mainly stored in platelets and circulates in blood. Recent reports indicate that serum BDNF levels in depressive patients are lower than in control subjects, and antidepressant treatment increases serum BDNF levels in responders. In the present study, we investigated the direct influence of antidepressants on BDNF release from platelets and their effects on serum levels. These results confirm that BDNF release from platelets is affected by antidepressants, which may relate to the circulating BDNF level change in peripheral blood. The response of BDNF release differs depending on the type and amount of antidepressants, making BDNF a serious candidate as a predictor of antidepressant treatment response.
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