A study on the pathophysiology of dementia with Lewy bodies (DLB) and the usefulness of Yokukan-san for the treatment of DLB and its functional mechanism

• Project/Area Number: 20790852
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: TATENO Masaru Sapporo Medical University, 医学部, 講師 (60464492)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: レビー小体型認知症 / レビー小体病 / アルツハイマー病 / アミロイドβ蛋白 / 抑肝散 / 脳血流SPECT / MIBG心筋シンチグラフィー / 細胞障害 / 脳・神経 / 神経科学 / 認知症 / アルツハイマー型認知症 / αシヌクレイン

Research Abstract

We examined the usefulness of statistical analysis programs of brain perfusion SPECT for the clinical diagnosis of dementia with Lewy bodies (DLB) and demonstrated the relation between occipital hypoperfusion and Parkinsonism, and orthostatic hypotension and the heart-to-mediastinum (H/M) ratio on MIBG myocardial scintigraphy. These results suggest that autonomic dysfunction plays an important role in the pathophysiology of DLB. In vitro study using primary culture of rat cortical neuron indicated that Yokukan-san had neuroprotective effect against beta amyloid protein (Aβ)-induced cytotoxicity.

Research Products

• [Journal Article] レビー小体型認知症とアルツハイマー病におけるアポリポ蛋白E4の頻度 (2010)
  • Author(s): 小林清樹, 内海久美子, 館農勝, 他
  • Journal Title: 老年精神医学雑誌 21 Pages: 253-260
  • Peer Reviewed
• [Journal Article] Imaging improves diagnosis of dementia with Lewy bodies. (2009)
  • Author(s): Tateno M, Kobayashi S, Saito T
  • Journal Title: Psychiatry Investigation 6 Pages: 233-240
  • Peer Reviewed
• [Journal Article] Two-layer appearance on brain perfusion SPECT in idiopathic normal pressure hydrocephalus: a qualitative analysis by using easy Z-score imaging system, eZIS. (2009)
  • Author(s): Kobayashi S, Tateno M, Utsumi K, et al.
  • Journal Title: Dement Geriatr Cogn Disord 28 Pages: 330-337
  • Peer Reviewed
• [Journal Article] Decreased cardiac MIBG uptake, its correlation with clinical symptoms in dementia with Lewy bodies. (2009)
  • Author(s): Kobayashi S, Tateno M, Morii H, et al.
  • Journal Title: Psychiatry Research: Neuroimaging 174 Pages: 76-80
  • Peer Reviewed
• [Journal Article] 特発性正常圧水頭症とアルツハイマー型認知症の鑑別におけるeZISの有用性 (2009)
  • Author(s): 小林清樹, 内海久美子, 館農勝, 他
  • Journal Title: 精神医学 51 Pages: 533-539
  • NAID: 40016580414
  • Peer Reviewed
• [Journal Article] レビー小体型認知症とアルツハイマー病におけるアポリポ蛋白E4の頻度 (2009)
  • Author(s): 小林清樹
  • Journal Title: 老年精神医学雑誌 21 Pages: 253-260
  • Peer Reviewed
• [Journal Article] Imaging improves diagnosis of dementia with Lewy bodies (2009)
  • Author(s): Masaru Tateno
  • Journal Title: Psychiatry Investigation 6 Pages: 233-240
  • Peer Reviewed
• [Journal Article] Two-layer appearance on brain perfusion SPECT in idiopathic normal pressure hydrocephalus : a qualitative analysis by using easy Z-score imaging system, eZIS (2009)
  • Author(s): Seiju Kobayashi
  • Journal Title: Dementia and Geriatric Cognitive Disorders 28 Pages: 330-337
  • Peer Reviewed
• [Journal Article] Decreased cardiac MIBG uptake, its correlation with clinical symptoms in dementia with Lewy bodies (2009)
  • Author(s): Seiju Kobayashi
  • Journal Title: Psychiatry Research : Neuroimaging 174 Pages: 76-80
  • Peer Reviewed
• [Journal Article] 特発性正常圧水頭症とアルツハイマー型認知症の鑑別におけるeZISの有用性 (2009)
  • Author(s): 小林清樹
  • Journal Title: 精神医学 51 Pages: 533-539
  • Peer Reviewed
• [Journal Article] Usefulness of a blood flow analyzing program 3DSRT to detect occipital hypoperfusion in dementia with Lewy bodies. (2008)
  • Author(s): Tateno M, Utsumi K, Kobayashi S, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1206-1209
  • Peer Reviewed
• [Journal Article] Quantitative analysis of the effects of donepezil on regional cerebral blood flow in Alzheimer's disease by using an automated program, 3DSRT. (2008)
  • Author(s): Tateno M, Kobayashi S, Utsumi K, et al.
  • Journal Title: Neuroradiology 50 Pages: 723-727
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. (2008)
  • Author(s): Tateno M, Ukai W, Ono T, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1704-1707
  • Peer Reviewed
• [Journal Article] Comparison of the usefulness of brain perfusion SPECT and MIBG myocardial scintigraphy for the diagnosis of dementia with Lewy bodies. (2008)
  • Author(s): Tateno M, Kobayashi S, Shirasaka T, et al.
  • Journal Title: Dement Geriatr Cogn Disord 26 Pages: 453-457
  • Peer Reviewed
• [Journal Article] Biological studies on alcohol-induced neuronal damage. (2008)
  • Author(s): Tateno M, Saito T
  • Journal Title: Psychiatry Investigation 5 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Lithium-induced suppression of transcription repressor NRSF/REST: Effects on the dysfunction of neuronal differentiation by ethanol. (2008)
  • Author(s): Ishii T, Hashimoto E, Ukai W, Tateno M, et al.
  • Journal Title: Eur J Pharmacol 593 Pages: 36-43
  • Peer Reviewed
• [Journal Article] Quantitative analysis of brain perfusion SPECT in Alzheimer's disease using a fully automated regional cerebral blood flow quantification software, 3DSRT. (2008)
  • Author(s): Kobayashi S, Tateno M, Utsumi K, et al.
  • Journal Title: J Neurol Sci 264 Pages: 27-33
  • Peer Reviewed
• [Journal Article] レビー小体型認知症におけるMIBG心筋シンチグラフィー (2008)
  • Author(s): 小林清樹, 館農勝, 古川美盛, 白坂知彦, 成田学, 高橋明, 安村修一, 森井秀俊, 藤井一輝, 内海久美子
  • Journal Title: 老年精神医学雑誌 19 Pages: 342-347
  • NAID: 40016093654
  • Peer Reviewed
• [Journal Article] MIBG心筋シンチグラフィーと脳血流SPECTを用いたレビー小体型認知症の診断精度向上の試み (2008)
  • Author(s): 小林清樹, 館農勝, 古川美盛, 白坂知彦, 内海久美子
  • Journal Title: 精神神経学雑誌 110 Pages: 285-291
  • NAID: 10024578204
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of Yi-Gan San against beta amyloidinduced cytotoxicity on rat cortical neurons (2008)
  • Author(s): Masaru Tateno
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1704-1707
  • Peer Reviewed
• [Journal Article] Usefulness of a blood flow analyzing program 3DSRT to detect occipital hypoperfusion in dementia with Lewy bodies (2008)
  • Author(s): Masaru Tateno
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 32 Pages: 1206-1209
  • Peer Reviewed
• [Journal Article] Quantitative analysis of the effects of donepezil on regional cerebral blood flow in Alzheimer's disease by using an automated program, 3DSRT (2008)
  • Author(s): Masaru Tateno
  • Journal Title: Neuroradiology 50 Pages: 723-727
  • Peer Reviewed
• [Journal Article] Comparison of the usefulness of brain perfusion SPECT and MIBG myo cardial scintigraphy for the diagnosis of dementia with Lewy bodies (2008)
  • Author(s): Masaru Tateno
  • Journal Title: Dement Geriatr Cogn Disord 26 Pages: 453-457
  • Peer Reviewed
• [Journal Article] Biological studies on alcoholinduced neuronal damage (2008)
  • Author(s): Masaru Tateno
  • Journal Title: Psychiatry Investigation 5 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Quantitative analysis of brain perfusion SPECT in Alzheimer's disease using a fully automated regional cerebral blood flow quantification soft ware, 3DSRT (2008)
  • Author(s): Seiju Kobayashi
  • Journal Title: J Neurol Sci 264 Pages: 27-33
  • Peer Reviewed
• [Journal Article] Lithiuminduced suppression of transcription repressor NRSF/REST : effects on the dysfunction of neuronal differentiation by ethanol (2008)
  • Author(s): Takao Ishii
  • Journal Title: Eur J Pharmacol 593 Pages: 36-43
  • Peer Reviewed
• [Journal Article] レビー小体型認知症におけるMIBG心筋シンチグラフィー (2008)
  • Author(s): 小林清樹
  • Journal Title: 老年精神医学雑誌 19 Pages: 342-347
  • Peer Reviewed
• [Journal Article] MIBG心筋シンチグラフィーと脳血流SPECTを用いたレビー小体型認知症の診断精度向上の試み (2008)
  • Author(s): 小林清樹
  • Journal Title: 精神神経学雑誌 110 Pages: 285-291
  • Peer Reviewed
• [Presentation] Neural stem cell and neurotrophins; their roles in the pathophysiology of depression International Conference on Depression and Suicide (2009)
  • Author(s): Tateno M
  • Organizer: Neuro-psychopharmacology and Transcultural Differences in Asia in the 21st Century
  • Place of Presentation: シンガポール大学
  • Year and Date: 2009-12-21
• [Presentation] Neural stem cell and neurotrophins ; their roles in the pathophysiology of depression (2009)
  • Author(s): Masaru Tateno
  • Organizer: International Conference on Depression and Suicide Neuro-psychopharmacology and Transcultural Differences in Asia in the 21st Century
  • Place of Presentation: シンガポール大学講堂(シンガポール)
  • Year and Date: 2009-12-21
• [Presentation] レビー小体型認知症におけるMIBG心筋シンチグラフィーの有用性 (2009)
  • Author(s): 小林清樹, 内海久美子, 館農勝, 他
  • Organizer: 第3回レビー小体型認知症研究会
  • Place of Presentation: 新横浜プリンスホテル(横浜)
  • Year and Date: 2009-11-07
• [Presentation] レビー小体型認知症におけるMIBG心筋シンチグラフィーの有用性 (2009)
  • Author(s): 小林清樹
  • Organizer: 第3回レビー小体型認知症研究会
  • Place of Presentation: 新横浜プリンスホテル(神奈川)
  • Year and Date: 2009-11-07
• [Presentation] アルツハイマー型認知症とレビー小体型認知症におけるアポリポ蛋白E (2009)
  • Author(s): 小林清樹, 内海久美子, 館農勝, 他
  • Organizer: 第24回日本老年精神医学会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-06-18
• [Presentation] アルツハイマー型認知症とレビー小体型認知症におけるアポリポ蛋白E (2009)
  • Author(s): 小林清樹
  • Organizer: 第24回日本老年精神医学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2009-06-18
• [Presentation] A long-term care model to support people with dementia by the entire community: Naka-sorachi local network. (Symposium SY2051: The long term care issues of Asian elderly) In (2008)
  • Author(s): Kobayashi S, Tateno M, Utsumi K, et al.
  • Organizer: The 13th Pacific Rim College of Psychiatry Scientific Meeting
  • Place of Presentation: 都市センターホテル(東京)
  • Year and Date: 2008-10-30
• [Presentation] Neuroprotective effects of atypical antipsychotics against ER stress-induced cell damage (2008)
  • Author(s): Masaru Tateno
  • Organizer: 2nd WFSBP AsiaPacific Congress
  • Place of Presentation: Toyama, Japan
  • Year and Date: 2008-09-13
• [Presentation] レビー小体型認知症の臨床診断におけるMIBG心筋シンチの有用性について (2008)
  • Author(s): 館農勝, 小林清樹, 内海久美子, 他
  • Organizer: 第23回日本老年精神医学会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-06-27
• [Presentation] 特発性正常圧水頭症とアルツハイマー型認知症の鑑別における脳血流SPECTの有用性 (2008)
  • Author(s): 小林清樹, 内海久美子,... 館農勝, 他(13人中10番目)
  • Organizer: 第23回日本老年精神医学会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2008-06-27
• [Presentation] レビー小体型認知症の臨床診断におけるMIBG心筋シンチの有用性について (2008)
  • Author(s): 館農勝
  • Organizer: 第23回日本老年精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-06-27