| Project/Area Number |
20790856
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
SHOYAMA Masaru Wakayama Medical University, 医学部, 助教 (70364081)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 統合失調症 / 認知機能障害 / 漢方 / 経頭蓋磁気刺激 / 神経生理指標 |
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| Research Abstract |
The aim of this study was to determine the effectiveness of traditional Japanese herbal medicine and a biological indicator for treatment of cognitive dysfunction in schizophrenia. First, we examined short latency afferent inhibition (SAI) after applying transcranial magnetic stimulation in schizophrenia patients and found that SAI was reduced in the patients as compared with control subjects. Next, we investigated the use of the traditional Japanese herbal medicine Yi-Gan San for treatment of psychological symptoms and cognitive dysfunction in patients with schizophrenia, delusional disorder, and dementia. Together, our findings indicate clinical improvements by use of herbal medicine and measurment of central cholinergic activity for treatment of cognitive dysfunction in patients with schizophrenia.
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