Behavioral physiological and molecular biological analyses of animal model for bipolar disorder
| Project/Area Number |
20790864
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KASAHARA Takaoki The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, 副チームリーダー (50344031)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 双極性障害 / 動物モデル / Polg1 / Wfs1 / メラトニン / リチウム / 気分障害 / ミトコンドリア / 遺伝子改変マウス / ウォルフラム症候群 / 光マスキング / 電気けいれん療法 / ラモトリギン / パルプロ酸 |
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| Research Abstract |
I analyzed wheel-running activity of an animal model for bipolar disorder, mutant Polg1 transgenic mice, for more than a half year. This shed light on the pathophysiology involving the seasonality or photoperiodicity. I obtained novel findings on melatonin synthesis of mice. In addition, I succeeded in treating mice with lithium, a mood stabilizer, more than three months without affecting health of mice. Using the method of lithium treatment, I investigated the effect of lithium on the longitudinal manifestations of the model mice.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder.2009
Author(s)
Hayashi, A., Kasahara, T., Kametani, M., Toyota, T., Yoshikawa, T., Kato, T.
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Journal Title
Int. J. Neuropsychopharmacol. 12
Pages: 33-43
Related Report
Peer Reviewed
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[Journal Article] Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder.2008
Author(s)
Kato, T., Ishiwata, M., Yamada, K., Kasahara T., Kakiuchi, C., Iwamoto, K., Kawamura, K., Ishihara, H., Oka, Y.
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Journal Title
Neurosci. Res. 61
Pages: 143-153
Related Report
Peer Reviewed
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[Journal Article] Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder.
Author(s)
Kubota, M., Kasahara, T., Iwamoto, K., Komori, A., Ishiwata, M., Miyauchi, T., Kato, T.
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Journal Title
Int. J. Neuropsychopharmacol. (in press)
Related Report
Peer Reviewed
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[Presentation] Transgenic mice with neuron-specific mitochondrial DNA defects as a model for bipolar disorder.2008
Author(s)
Kasahara, T., Kubota, M., Miyauchi, T., Ishiwata, M., Kato, T.
Organizer
Euromit7
Place of Presentation
ストックホルム, スウェーデン
Related Report
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