Genetic analyses of FABP genes in functional psychoses

• Project/Area Number: 20790867
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YIWAYAMA Yoshimi The Institute of Physical and Chemical Research, 分子精神科学研究チーム, リサーチアソシエイト (60399441)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 統合失調症 / 双極性障害 / FABP遺伝子 / 不飽和脂肪酸 / 関連研究 / 死後脳発現解析 / 再シークエンシング / ミスセンス変異 / 結晶解析 / 機能性精神疾患 / FABP7 / FABP5 / FABP3 / 関連解析 / 死後脳発現

Research Abstract

Deficits in prepulse inhibition (PPI) are a biological marker for psychiatric illnesses such as schizophrenia and bipolar disorder. To unravel PPI-controlling mechanisms, we previously performed quantitative trait loci analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene. FABPs constitute a gene family, of which members FABP5 and FABP3 are also expressed in the brain. In this project, I examined the genetic roles of these FABP genes in schizophrenia and bipolar disorder. FABP7 showed nominal association with bipolar disorder (we previously reported an association of FABP7 with schizophrenia). We could not obtain evidence for associations of FABP5 and FABP3 with either disease.

Research Products

• [Journal Article] Association analyses between brain-expressed FABP (fatty-acid binding protein) genes and schizophrenia and bipolar disorder. (2010)
  • Author(s): Iwayama Y., Hattori E., Maekawa M., Yamada K., Toyota T., Ohnishi T., Iwata Y., Tsuchiya K., Sugihara G., Kikuchi M., Hashimoto K., Iyo M., Inada T., Kunugi H., Okazaki N., Iwata N., Nanko S., Iwamoto K., Okazaki Y., Kato T., Yoshikawa T.
  • Journal Title: Am. J. Med. Genet. Part B. 153B Pages: 484-493
  • Peer Reviewed
• [Journal Article] Polymorphism screening of brain-expressed FABPs7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. (2010)
  • Author(s): Maekawa M., Iwayama Y., Arai R., Nakamura K., Ohnishi T., Toyota T., Tsujii M., Okazaki Y., Osumi N., Owada Y., Mori N., Yoshikawa T.
  • Journal Title: J. Hum. Genet. 55 Pages: 127-130
  • Peer Reviewed
• [Journal Article] Association analyses between brain-expressed FABP(fatty-acid binding protein)genes and schizophrenia and bipolar disorder (2010)
  • Author(s): Yoshimi I.
  • Journal Title: Am.J.Med.Genet.Part B (in press)
  • Peer Reviewed
• [Journal Article] Polymorphism screening of brain-expressed FABPs7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects (2010)
  • Author(s): Motoko M.
  • Journal Title: J.Hum.Genet (in press)
  • Peer Reviewed
• [Journal Article] Genetic examination of the PLXNA2 gene in Japanese and Chinese schizophrenics (2008)
  • Author(s): Takeshita M.
  • Journal Title: Schizophrenia Research 99 Pages: 359-364
  • Peer Reviewed
• [Journal Article] Association between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder (2008)
  • Author(s): Amano K.
  • Journal Title: Psychiatric Genetics 18 Pages: 1-10
  • Peer Reviewed
• [Journal Article] SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects (2008)
  • Author(s): Lepagnol-Bestel A-M
  • Journal Title: Mol. Psychiatry 13 Pages: 385-397
  • Peer Reviewed
• [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder (2008)
  • Author(s): Anitha A.
  • Journal Title: Biol. Psychiatry 63 Pages: 678-685
  • Peer Reviewed
• [Journal Article] Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism (2008)
  • Author(s): Anitha A.
  • Journal Title: Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B Pages: 1019-1027
  • Peer Reviewed
• [Journal Article] Genetic and expression analyses revealed elevated expression of syntaxin 1A (STXIA) in high functioning autism (2008)
  • Author(s): Nakamura K.
  • Journal Title: The International Journal of Neuropsychopharmacology 11 Pages: 1073-1084
  • Peer Reviewed
• [Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations
  • Author(s): Yamada K.
  • Journal Title: Am. J. Med. Genet. B Neuropsychiatr. Genet. (in press)
  • Peer Reviewed
• [Journal Article] Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia
  • Author(s): Hattori E.
  • Journal Title: Eur. J. Hum. Genet. (in press)
  • Peer Reviewed
• [Journal Article] Association studies and gene expression analyses of the DISCI-interacting molecules, pericentrin 2 (PCNT2) and DISCI-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder
  • Author(s): Anitha A.
  • Journal Title: Neuropsychiatr. Genet. (in press)
  • Peer Reviewed
• [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population
  • Author(s): Hattori E.
  • Journal Title: Neuropsychiatr. Genet. (in press)
  • Peer Reviewed
• [Presentation] Examination of etiological roles of FABP7 (2008)
  • Author(s): Yoshimi Iwayama
  • Organizer: 5 and 3 in functional psychoses XVIth World Congress on Psychiatric Genetics Confirmation
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2008-10-11
• [Presentation] Examination of etiological roles of FABP7, 5 and 3 in functional psychoses (2008)
  • Author(s): Iwayama Y.
  • Organizer: XVIth World Congress on Psychiatric Genetics Confirmation
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2008-10-11
• [Remarks]
  • URL: http://www.riken.jp/engn/r-world/research/lab/nokagaku/age/molecular/index.html
• [Remarks]
  • URL: http://www.riken.jp/engn/r-world/research/lab/nokagaku/age/molecular/index.html