| Project/Area Number |
20790870
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
FUJII Takashi National Center of Neurology and Psychiatry, 神経研究所・疾病研究第三部, 流動研究員 (10450610)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 臨床精神分子遺伝学 / Plexin / Semaphorin / 脳神経疾患 / 神経科学 |
|---|
| Research Abstract |
Based on the neurodevelopmental hypothesis in the etiology of schizophrenia, the plexin/semaphorin genes might be involved in the pathogenesis of the illness. We searched for non-synonymous polymorphisms of these genes in silico based on the NCBI dbSNP database. Detected polymorphisms were subject to association analyses with neuropsychiatric diseases. In a series of studies, we found a significant association between the Lys701Gln polymorphism of SEMA3D and schizophrenia, genotyping a sample of 506 patients with schizophrenia and 941 healthy control subjects. The Gln701 allele showed a significant protective effect against the development of schizophrenia (p=0.0069). In addition, the haplotype rs2190208-rs1029564-rs17159614-rs121176601, not including the Lys701G1n variant, was shown to be associated with schizophrenia (p=0.00001), which suggests that some other polymorphisms of SEMA3D play a role in the pathogenesis of schizophrenia. Our findings provide strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder.
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