Estimation of coronary endothelial dysfunction in metabolic syndrome and effects of treatment on the dysfunction

• Project/Area Number: 20790871
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: NAYA Masanao Hokkaido University, 大学院・医学研究科, 非常勤講師 (20455637)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 循環器 / PET / 心筋血流量 / メタボリックシンドローム / 核医学(PETを含む) / 冠血管予備能 / 冠血管内皮機能

Research Abstract

Coronary vascular reactivity assessed by PET and cold pressor test was reduced and its severity was associated with serum LDL cholesterol and oxidative stress in patients with metabolic syndrome. Reduction of coronary flow reserve was associated coronary plaque extent in patients with more advanced coronary artery disease. These results suggest that coronary atherosclerosis is observed even in metabolic syndrome patients without symptoms of angina and progresses to the atherosclerotic plaque and reduction of coronary flow reserve.

Research Products

• [Journal Article] Quantification of Myocardial Blood Flow Using Rubidium-82 PET (2010)
  • Author(s): Tamaki N, Yoshinaga K, Naya M
  • Journal Title: Eur J Nucl Med Mol Imaging (in press)
  • Peer Reviewed
• [Journal Article] Myocardial β-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy. (2009)
  • Author(s): Naya M, Tsukamoto T, Morita K, Katoh C, Nishijima K, Komatsu H, Yamada S, Kuge Y, Tamaki N, Tsutsui H
  • Journal Title: J Nucl Med Vol50 Pages: 220-224
  • Peer Reviewed
• [Journal Article] Repeatability of rest and hyperemic myocardial blood flow measurements with 82Rubidium dynamic PET. (2009)
  • Author(s): Manabe O, Yoshinaga K, Katoh C, Naya M, deKemp R, Tamaki N
  • Journal Title: I Nucl Med Vol50 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Myocardial β-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy (2009)
  • Author(s): Naya M, Tsukamoto T, Morita K, Katoh C, Nishijima K, Komatsu H, Yamada S, Kuge Y, Tamaki N, Tsutsui H
  • Journal Title: J Nucl Med 50 Pages: 220-225
  • Peer Reviewed
• [Journal Article] Repeatability of rest and hyperemic myocardial blood flow measurements with ^<82>Rubidium dynamic PET (2009)
  • Author(s): Manabe O, Yoshinaga K, Katoh C, Naya M, deKemp R, Tamaki N
  • Journal Title: J Nucl Med 50 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Myocardial β-adrenergic receptor density assessed by ^<11>C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy (2009)
  • Author(s): Masanao Naya, Takahiro Tsukamoto, Koichi, Morita, Chietsugu Katoh et.al.
  • Journal Title: Journal of Nuclear Medicine 50 Pages: 220-225
  • Peer Reviewed
• [Journal Article] Repeatability of Rest and Hyperemic Myocardial Blood Flow Measure ments with ^<82>Rb Dynamic PET (2008)
  • Author(s): Osamu Manabe, Keiichiro Yoshinaga, Chietsugu Katoh, Masanao Nava, et.al.
  • Journal Title: Journal of Nuclear Medicine 50 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Quantification of Myocardial Blood Flow Using Rubidium-82 PET
  • Author(s): Tamaki N, Yoshinaga K, Naya M
  • Journal Title: Eur J Nucl Med Mol Imaging (In press)
  • Peer Reviewed
• [Presentation] 82Rubidium PETにおける局所心筋血流量計測の再現性 (2009)
  • Author(s): 吉永恵一郎, 真鍋治, 加藤千恵次, 納谷昌直, Ran Klein, Dekemp Robert, 西嶋剣一, 鈴間鏡太郎, 玉木長良
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] ジェネレータ産生82Rubidiumを用いた新たな心筋血流PETによる冠血管内皮機能計測の妥当性-15O water PETとの比較- (2009)
  • Author(s): 吉永恵一郎, 真鍋治, 加藤千恵次, 納谷昌直, deKemp RA, 玉木長良
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-18
• [Presentation] 冠動脈イベント発症リスク層別化における冠動脈MDCTの役割の検討~負荷心筋血流シンチグラフィーとの比較~ (2009)
  • Author(s): 後藤大祐, 納谷昌直, 古本智夫, 玉木長良筒井裕之
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-18
• [Presentation] Effects of smoking cessation on coronary endothelial dysfunction in young and middle-aged healthy smokers (2009)
  • Author(s): 納谷昌直、 森田浩一、 塚本隆裕、 吉永恵一郎ら
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-20
• [Presentation] Rubidium-82 (Rb-82) PETによる心筋血流量の測定及びその再現性 (2009)
  • Author(s): 真鍋治, 吉永恵一郎, 加藤千恵次, 納谷昌直, 玉木長良
  • Organizer: 第26回北海道心臓核医学研究会
  • Place of Presentation: 札幌
  • Year and Date: 2009-03-07
• [Presentation] Myocardial oxidative metabolism in patients with aortic valve stenosis. (2009)
  • Author(s): Naya M, Keiichiro Y, Sugiki T, Iwano H, Kuge Y, Yamada S, Katoh C, Matsui Y, Tsutsui H, Tamaki N.
  • Organizer: Society of Nuclear Medicine
  • Place of Presentation: Tronto, Canada
• [Presentation] Accelerated Tc-99m-sestamibi clearances associated with mitochondrial dysfunction in reperfused myocardium in acute coronary syndrome. (2009)
  • Author(s): Yoshinaga K, Naya M, Katoh C, Kuge Y, Manabe O, Yamada S, Tsutsui H, Tamaki N.
  • Organizer: Society of Nuclear Medicine
  • Place of Presentation: Tronto, Canada
• [Presentation] Repeatability of regional Rest and Hyperemic Myocardial Blood Flow with Rubidium-82 PET. (2009)
  • Author(s): Yoshinaga K, Manabe O, Katoh C, Naya M, Klein R, deKemp RA, Beanlands RSB, Tamaki N.
  • Organizer: Society of Nuclear Medicine
  • Place of Presentation: Tronto, Canada
• [Presentation] Myocardial oxidative metabolism and effects of mitral valvuloplasty in patients with mitral regurgitation and with preserved LVEF. (2009)
  • Author(s): Sugiki T, Naya M, Yoshinaga K, Tamaki N, Tsutsui H, Matsui Y.
  • Organizer: Society of Nuclear Medicine
  • Place of Presentation: Tronto, Canada
• [Presentation] Effects of smoking cessation on coronary endothelial dysfunction in young and middle-aged healthy smokers. (2009)
  • Author(s): Naya M, Morita K, Tsukamoto T, Yoshinaga K, Kuge Y, Katoh C, Tamaki N, Tsutsui H.
  • Organizer: ICNC09
  • Place of Presentation: Barcelona, Spain
• [Presentation] 82Rubidium (82Rb)を用いた心筋血流量「MBF(myocardial blood flow)」計測の再現性-性差による違いは存在するか- (2009)
  • Author(s): 真鍋治, 吉永恵一郎, 加藤千恵次, 納谷昌直, 玉木長良
  • Organizer: 第68回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] Effects of smoking cessation on coronary endothelial dysfunction in young and middle-aged healthy smokers. (2009)
  • Author(s): Naya M, Keiichiro Y, Sugiki T, Iwano H, Kuge Y, Yamada S, Katoh C, Matsui Y, Tsutsui H, Tamaki N
  • Organizer: The 73rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka, Japan
• [Presentation] Surgical ventricular reconstruction improves myocardial oxidative efficiency assessed by 11C-acetate PET and echocardiography in patients with severe heart failure. (2009)
  • Author(s): Sugiki T, Naya M, Yoshinaga K, Tamaki N, Tsutsui H, Matsui Y.
  • Organizer: The 73rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka, Japan
• [Presentation] Development of coronary endothelial function measurements with generator produced 82Rubidium PET ? comparison with oxygen 15-labeled water PET -. (2009)
  • Author(s): Yoshinaga K, Manabe O, Katoh C, Naya M, deKemp RA, Tamaki N.
  • Organizer: The 73rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka, Japan
• [Presentation] Myocardial oxidative metabolism in patients with aortic valve stenosis (2009)
  • Author(s): Naya M, Keiichiro Y, Sugiki T, Iwano H, Kuge Y, Yamada S, Katoh C, Matsui Y, Tsutsui H, Tamaki N
  • Organizer: Society of Nuclear Medicine 2009
  • Place of Presentation: トロント、カナダ
• [Book] 見て診て学ぶ虚血性心疾患の画像診断 (2009)
  • Author(s): 玉木長良、納谷昌直
  • Publisher: 永井書店出版
• [Book] 見て診て学ぶ虚血性心疾患の画像診断(核医学) (2009)
  • Author(s): 玉木長良, 納谷昌直
  • Publisher: 永井書店出版