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Basical study for curing malignant brain tumor with carbon-ion beam therapy

Research Project

Project/Area Number 20790877
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

SUZUKI Yoshiyuki  Gunma University, 大学院・医学系研究科, 講師 (60334116)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords炭素イオン線 / 悪性脳腫瘍 / 遊走能 / 増感剤 / ニューロン
Research Abstract

1) According to the rate of radiation induced apoptosis, effect of Carbon-ion beam to immature neuron was about ten times higher than that of X-ray.
2) As for glial cell, there was little difference in X-ray radiosensitivity between immature and mature cells. X-ray radiosensitivity of glial cell was a little low compared with that of neuronal cell.
3) As for anti-tumor effect, the effect of X-ray with concurrent TMZ was 1.6 times higher than that without TMZ. Moreover, the effect of X-ray with concurrent TMZ and GYKI52466 was 10% higher than that with TMZ alone in the brain transplant model. As for RBE, when TMZ was used concurrently, the RBE of carbon-ion beam to X-ray was estimated about 3, similar to the RBE without TMZ in in vivo model. Also, the combinational effect of TMZ was an additive effect. As for cell motility, though the motility of tumor cell was enhanced by X-ray alone, it was completely controled by the use of ether TMZ or GYKI52466.
4) Concurrent use of TMZ with carbon-ion beam did not enhance the radiation effect.
5) Expression of Akt and PDK1 in malignant brain tumor cell were increased by X-ray irradiation and the increased expression of PDK1 correlated to activation of cell motility. In clinical, strong expression of activated Akt and PDK1 were significant poor prognostic factor in the Glioblastoma patients treated with radiation therapy..

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (13 results)

  • [Journal Article] Usefulness of Intraluminal Brachytherapy combined with External Beam Radiation Therapy for Submucosal Esophageal Cancer2010

    • Author(s)
      Ishikawa H, Nonaka T, Suzuki Y, et, al.
    • Journal Title

      Int J Radiat Oncol Biol Phys. 76(2)

      Pages: 452-459

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current advancement in radiation therapy for uterine cervical cancer2010

    • Author(s)
      Nakano T, Ohno T, Ishikawa H, Suzuki Y, Takahashi T
    • Journal Title

      J Radiat Res (Tokyo). 51

      Pages: 1-8

    • NAID

      10025913850

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas2010

    • Author(s)
      Suzuki Y, Shirai K, Oka K, et, al.
    • Journal Title

      J Radiat Res (Tokyo) (in press)

    • NAID

      10026471315

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survivin is a Potential Mediator of Prostate Cancer Metastasis2010

    • Author(s)
      Zhang M, Coen JJ, Suzuki Y, et, al.
    • Journal Title

      Int J Radiat Oncol Biol Phys. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survivin is a Potential Mediator of Prostate Cancer Metastasis2010

    • Author(s)
      Zhang M, Coen JJ, Suzuki Y, et al.
    • Journal Title

      International Journal of Radation Oncology/Biology/Phys (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas2010

    • Author(s)
      Suzuki Y, Shirai K, Oka K, et al.
    • Journal Title

      Journal of Radation Research (in press)

    • NAID

      10026471315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current advancement in radiation therapy for uterine cervical cancer2010

    • Author(s)
      Nakano T, Ohno T, Suzuki Y, et al.
    • Journal Title

      Journal of Radation Research 51

      Pages: 1-8

    • NAID

      10025913850

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of Intraluminal Brachytherapy combined with External Beam Radiation Therapy for Submucosal Esophageal Cancer2010

    • Author(s)
      Ishikawa H, Nonaka T, Suzuki Y, et al.
    • Journal Title

      International Journal of Radation Oncology/Biology/Phys 76(2)

      Pages: 452-459

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Survivin Expression Predicts Poorer Prognosis in Glioblastoma2009

    • Author(s)
      Shirai K, Suzuki Y, Oka K, et al.
    • Journal Title

      J Neurooncol 91(3)

      Pages: 353-358

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Mitotic Index Of Proliferating Cell Populations (pMI) in Cervical Cancer Patients Treated with Carbon2009

    • Author(s)
      Suzuki Y, Nakano N, Ohno T, et, al.
    • Journal Title

      Ion Beam. Cancer. 115(9)

      Pages: 1875-1882

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Value of Survivin in Locally Advanced Prostate Cancer2009

    • Author(s)
      Zhang M, Ho A, Hammond EH, Suzuki Y, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys. 15;73(4)

      Pages: 1033-1042

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The radiobiological effectiveness of carbon- ion beams on growing neurons2009

    • Author(s)
      Al-Jahdari W, Suzuki Y, Yoshida Y, et, al.
    • Journal Title

      Int J Radat Biol. 85(8)

      Pages: 700-709

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Technological Advances in Radiation Oncology for Central Nervous System Tumors2009

    • Author(s)
      Noda S, Lautenschlaeger T, Suzuki Y, et, al.
    • Journal Title

      Semin Radiat Oncol. 19(3)

      Pages: 179-186

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Irradiation on the Development of Immature Hippocampal Neurons In Vitro.2009

    • Author(s)
      Okamoto M, Suzuki Y, Shirai K, et al.
    • Journal Title

      Radiat Res. 172(6)

      Pages: 718-724

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Irradiation on the Development of Immature Hippocampal Neurons In Vitro2009

    • Author(s)
      Okamoto M, Suzuki Y.Shirai K, et al.
    • Journal Title

      Radiation Resarech 172(6)

      Pages: 718-724

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Technological Advances in Radiation Oncology for Central Nervous System Tumors2009

    • Author(s)
      Noda SE, Lautenschlaeger T.Suzuki Y., et al.
    • Journal Title

      Seminers in Radiation Oncology 19(3)

      Pages: 179-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The radiobiological effectiveness of carbon- ion beams on growing neurons2009

    • Author(s)
      Al-Jahdari W, Suzuki Y.Yoshida Y, et al.
    • Journal Title

      International Journal of Radation Biology 85(8)

      Pages: 700-709

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Value of Survivin in Locally Advanced Prostate Cancer : Study Based on RTOG 8610.2009

    • Author(s)
      Zhang M, Ho A, Suzuki Y, et al.
    • Journal Title

      International Journal of Radation Oncology/Biology/Phys 73(4)

      Pages: 1033-1042

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Mitotic Index Of Proliferating Cell Populations(pMI)in Cervical Cancer Patients Treated with Carbon Ion Beam2009

    • Author(s)
      Suzuki Y, Nakano N, Ohno T, et al.
    • Journal Title

      Cancer 115(9)

      Pages: 1875-1882

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Survivin Expression Predicts Poorer Prognosis in Glioblastoma2009

    • Author(s)
      Shirai K, Suzuki Y.Oka K, et al.
    • Journal Title

      Journal of Neuro-Oncology 91(3)

      Pages: 353-358

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Mitotic Index Of Proliferating Cell Populations (pMI) in Cervical Cancer Patients Treated with Carbon Ion Beam2009

    • Author(s)
      Suzuki Y, Nakano N, Ohno T, Kato S, Tsujii H, Oka K
    • Journal Title

      Cancer (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth cone collapse and neurite 'retractions : An approach to examine X-irradiation affects on neuron cells2009

    • Author(s)
      Al-Jandari WS, Suzuki Y, Yoshida Y, et.al.
    • Journal Title

      J Radiat Res 49

      Pages: 481-489

    • NAID

      110006935554

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the radiobiological' effect of carbon ion beam therapy and conventional radiation therapy on cervical cancer2008

    • Author(s)
      Suzuki Y, Nakano T, Ohno T, Oka K
    • Journal Title

      J Radiat Res 49

      Pages: 473-479

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Carbon beam therapy overcomes hypoxia-originating radiation -resistant nature of uterine cervical cancer.2010

    • Author(s)
      Suzuki Y
    • Organizer
      ERSC Winter Symposium
    • Place of Presentation
      Maebashi, Japan(Invited lecture)
    • Year and Date
      2010-02-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Carbon beam therapy overcame overcomes hypoxia-originating radiation-resistantnature of uterine cervical cancer2010

    • Author(s)
      鈴木義行
    • Organizer
      ERSC Winter Symposium
    • Place of Presentation
      Maebashi, Japan
    • Year and Date
      2010-02-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光子線および重粒子線治療された子宮頸癌患者における、放射線治療中の細胞動態と治療効果2010

    • Author(s)
      鈴木義行
    • Organizer
      第12回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良、奈良
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 新時代の免疫療法と高精度放射線治療の併用治療戦略2009

    • Author(s)
      鈴木義行
    • Organizer
      群馬大学がんプロフェッショナル養成プランインテンシブコース第1回
    • Place of Presentation
      前橋、群馬
    • Year and Date
      2009-05-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 新時代の免疫療法と高精度放射線治療の併用治療載略2009

    • Author(s)
      鈴木義行
    • Organizer
      群馬大学 がんプロフェッショナル養成プランインテンシブコース 第1回
    • Place of Presentation
      前橋、群馬
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role Of Nitric Oxide (NO) In Hypoxic Cancer cells Radio-Sensitivity ASTRO2009

    • Author(s)
      Al-Jahdari WS, Suzuki Y, et, al.
    • Organizer
      the 2009 Annual meeting
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Multisession Cyberknife radiosurgery for large brain metastasis Inter. Stereotactic Radiosurgery2009

    • Author(s)
      Inoue K, Nozaki A, Suzuki Y, et, al
    • Organizer
      Stereotactic Radiosurgery, Jun.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] Role Of Nitric Oxide(NO)In Hypoxic Cancer cells Radio-Sensitivity2009

    • Author(s)
      W.S.Al-Jahdari, Y.Suzuki, et al
    • Organizer
      ASTRO : the 2009 Annual meeting
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prognostic Impact of Mitotic Index Of Proliferating Cell Populations(pMI)in Cervical Cancer Patients Treated with Carbon Ion Beam2009

    • Author(s)
      Y.Suzuki, K.Oka, et al
    • Organizer
      PTCOG : the 48th meeting
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multisession Cyberknife radiosurgery for large brain metastasis2009

    • Author(s)
      Inoue K, Nozaki A, Y.Suzuki, et al
    • Organizer
      International Stereotactic Radiosurgery
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prognostic Impact of Mitotic Index Of Proliferating Cell Populations (pMI) in Cervical Cancer Patients Treated with Carbon Ion Beam. PTCOG2008

    • Author(s)
      Y. Suzuki, K. Oka, et, al
    • Organizer
      the 48th meeting
    • Place of Presentation
      Heidelberg, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro, fractionation enhances cells motility2008

    • Author(s)
      Suzuki Y
    • Organizer
      50th Annual meeting of American Sciety for The rapeutic Radiation Oncology
    • Place of Presentation
      Boston, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical application of Si/Cd compton imaging device2008

    • Author(s)
      Suzuki Y
    • Organizer
      4th COE International meeting
    • Place of Presentation
      Maebashi, Japan
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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