| Project/Area Number |
20790883
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTO Masami The University of Tokyo, 医学部・附属病院, 診療放射線技師 (30375844)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | MRI / 3.0T / 老化 / VBM / 海馬 / 脳容積 / 認知症 / 健常人 / エストロゲン / 閉経 / 非侵襲 |
|---|
| Research Abstract |
T1-weighted magnetic resonance images of healthy adults divided into eight groups by age and gender were obtained to analyze brain volume change. Significantly smaller gray matter volume was observed in the hippocampus bilaterally in females aged in their fifties (fifty one of 59 females were at menopause) compared to females in their forties (the only three of 46 females were at menopause), with voxel-based morphometry (VBM). However, No significant difference were found between the female groups in fifties vs sixties, sixties vs seventies, or the male groups in forties vs fifties, fifties vs sixties, sixties vs seventies. The results of our study suggest that the menopause may be associated with hippocampal volume reduction.
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