An application of accelerator produced alpha-emitting radionuclide for radionuclide therapy

• Project/Area Number: 20790886
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: WASHIYAMA Kohshin Kanazawa University, 保健学系, 助教 (80313675)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アイソトープ治療 / アルファ線 / in vivoジェネレーター / α放射体 / サイクロトロン / トリウム / Radionuclide Therapy / In vivo generator / RI治療 / がん治療

Research Abstract

Targeted alpha therapy (TAT) has been applied for cancer therapy and many clinical studies have been performed. Uranium-230 is a promising cyclotron produced alpha-emitting radionuclide for TAT. According to the reaction ^<232>Th(p, 3n)^<230>Pa and following the β- decay of ^<230>Pa, ^<230>U can be produced within the irradiated target. The daughter of ^<230>U, ^<226>Th (T_<1/2>=31m) provides a rapid cascade of 4 alpha particles with a 27.7MeV of total energy. In this study, we investigated the availability of production and radiochemical separation of ^<230>U and its daughters. Protactinium-230 was produced by irradiation of ^<232>ThO_2 target. After irradiation, the target was separated and ^<230>U/^<226>Th generator was constructed. Eluted ^<226>Th from generator was radiolabeled with bone seeking chelate, EDTMP and injected into mice for biodistribution evaluation. Most of all radioactivity were retained on bone.

Research Products

• [Journal Article] Biological safety of nasal thallium-201 administration : a preclinical study for olfacto-scintigraphy. (2011)
  • Author(s): K.Washiyama, H.Shiga, K.Hirota, A.Tsuchida, J.Yamamoto, S.Yagi, T.Yoshizaki, M.Furukawa, R.Amano, T.Miwa.
  • Journal Title: Journal of Radiation Research Volume: 52(In press)
  • Peer Reviewed
• [Journal Article] アルファ線を利用した核医学治療 (2010)
  • Author(s): 鷲山幸信
  • Journal Title: PET journal. 9 Pages: 36-38
• [Journal Article] アルファ線を利用した核医学治療 (2010)
  • Author(s): 鷲山幸信
  • Journal Title: PETjournal Volume: 9 Pages: 36-38
• [Journal Article] Biodistribution of Riken multitracer (MT) and MT-EDTMP, MT-DOTMP in mice. (2009)
  • Author(s): Wahiyama K
  • Journal Title: PIKEN Accel Prog Rep. 42 Pages: 264-264
  • Peer Reviewed
• [Journal Article] Odor detection ability and thallium-201 transport in the olfactory nerve of traumatic olfactory-impaired mice (2008)
  • Author(s): Shiga H, Kinoshita Y, Washiyama K, Ogawa D, Amano R, Hirota K, Tsukatani T, Furukawa M, Miwa T.
  • Journal Title: Chemical Senses 33(7) Pages: 633-7
  • Peer Reviewed
• [Journal Article] αvβ_3 Integrin-targeting radionuclide therapy and imaging with monomeric RGD peptide (2008)
  • Author(s): Yoshimoto M, Ogawa K, Washiyama K, Shikano N, Mori H, Amano R, Kawai K.
  • Journal Title: International Journal of Cancer 123(3) Pages: 709-15
  • Peer Reviewed
• [Journal Article] 自動血球計測装置pocH-100iVとKX-21NVを用いたマウス血球計測に関する基礎的検討 (2008)
  • Author(s): 鷲山幸信、大波加真弘、天野良平
  • Journal Title: Sysmex Journal 31 Pages: 25-37
  • Peer Reviewed
• [Presentation] 核医学治療を目指した^<230>Uの製造と^<230>U/^<226>Thジェネレーターの開発 (2010)
  • Author(s): 鷲山幸信, 高橋成人, 篠原厚, 横山明彦, 天野良平
  • Organizer: 第10回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都府民総合交流プラザ(京都府)
  • Year and Date: 2010-12-04
• [Presentation] 核医学治療を目指した^<230>Uの製造と^<230>U/^<226>Thジェネレーターの開発 (2010)
  • Author(s): 鷲山幸信, 高橋成人, 篠原厚, 横山明彦, 天野良平
  • Organizer: 第10回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都テルサ/京都府民総合交流プラザ(京都府)
  • Year and Date: 2010-12-04
• [Presentation] アルファ放射体を用いた転移性骨腫瘍の治療 (2010)
  • Author(s): 鷲山幸信, 山村朝雄, 佐藤伊佐務, 三頭聡明, 高橋成人, 篠原厚, 横山明彦, 天野良平
  • Organizer: 第54回放射化学討論会
  • Place of Presentation: 大阪大学吹田キャンパス銀杏会館(大阪府)
  • Year and Date: 2010-09-29
• [Presentation] 核医学治療の将来-α放出核種の応用-アルファ線を利用した核医学治療 (2010)
  • Author(s): 鷲山幸信
  • Organizer: 第43回日本核医学会近畿地方会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2010-07-24
• [Presentation] アルファ放射体を用いた転移性骨腫瘍の治療-核種の違いによる治療効果への影響検討- (2010)
  • Author(s): 鷲山幸信、山村朝雄、佐藤伊佐務、三頭聰明、高橋成人、篠原厚、横山明彦、天野良平
  • Organizer: 第54回放射化学討論会
  • Place of Presentation: 大阪大学吹田キャンパス銀杏会館(大阪府)
• [Presentation] α核種による治療の基礎と応用 (2009)
  • Author(s): 鷲山幸信
  • Organizer: 第49回日本核医学会学術集会
  • Place of Presentation: 旭川グランドホテル(北海道)
  • Year and Date: 2009-10-01
• [Presentation] 加速器を用いたアルファ放射体^<230>Uの製造および分離精製に関する基礎的検討 (2009)
  • Author(s): 鷲山幸信
  • Organizer: 第53回放射化学討論会
  • Place of Presentation: 日本大学文理学部百周年記念館会館(東京都)
  • Year and Date: 2009-09-28
• [Presentation] 核医学と放射化学の学際領域-核医学治療の最前線- (2009)
  • Author(s): 鷲山幸信
  • Organizer: 第53回放射化学討論会
  • Place of Presentation: 日本大学文理学部百周年記念館会館(東京都)
  • Year and Date: 2009-09-28
• [Presentation] Uptake of Pb-203 tracer in the olfactory bulbs via olfactory pathwaysin mice (2008)
  • Author(s): K. Washiyama, H. Koshida, R. Nakamura, N. Takahashi, T. Nanri, M. Araki, A. Yokoyama, A. Shinohara, T. Takayama, R. Amano
  • Organizer: The 21st Annual Meeting of European Associationof Nuclear Medicine
  • Place of Presentation: ICM(Munich, Germany)