Estrogen receptor imaging for diagnosis of uterine tumors

• Project/Area Number: 20790887
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: TSUJIKAWA Tetsuya University of Fukui, 医学部・附属病院, 医員 (30380033)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 核医学 / PET / 分子イメージング / エストロゲン受容体 / 糖代謝 / 子宮体癌 / 子宮内膜癌 / FES-PET / FDG-PET

Research Abstract

FES-PET combined with FDG would be useful for non-invasive evaluation of ERα distribution, as well as ERα function, which reflects differentiation grade, in endometrial carcinoma.

Research Products

• [Journal Article] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. (2010)
  • Author(s): Tsujikawa T, Yoneda M, Shimizu Y, Uematsu H, Toyooka M, Ikawa M, Kudo T, Okazawa H, Kuriyama M, Kimura H.
  • Journal Title: Brain Dev. 32 Pages: 143-9
  • NAID: 10027213011
  • Peer Reviewed
• [Journal Article] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images (2010)
  • Author(s): Tsujikawa T, et al.
  • Journal Title: Brain and Development 32 Pages: 143-149
  • NAID: 10027213011
  • Peer Reviewed
• [Journal Article] Functional images reflect aggressiveness of endometrial carcinoma: Estrogen receptor expression combined with FDG-PET. (2009)
  • Author(s): Tsujikawa T, Yoshida Y, Kudo T, Kiyono Y, Kurokawa T, Kobayashi M, Tsuchida T, Fujibayashi Y, Kotsuji F, Okazawa H.
  • Journal Title: J Nucl Med. 50 Pages: 1598-60
  • Peer Reviewed
• [Journal Article] Assessment of fluorodeoxyglucose uptake by leiomyomas in relation to histopathologic subtype and the menstrual state. (2009)
  • Author(s): Yoshida Y, Tsujikawa T, Kurokawa T, Tsuji T, Imamura Y, Fujibayashi Y, Okazawa H, Kotsuji F.
  • Journal Title: J Comput Assist Tomogr 33 Pages: 877-81
  • Peer Reviewed
• [Journal Article] Functional images reflect aggressiveness of endometrial carcinoma : Estrogen receptor expression combined with FDG-PET (2009)
  • Author(s): Tsujikawa T, et al.
  • Journal Title: The Journal of Nuclear Medicine 50 Pages: 1598-1604
  • Peer Reviewed
• [Journal Article] Assessment of FDG uptake by leiomyomas in relation to histopathological subtype and the menstrual state (2009)
  • Author(s): Yoshida Y, Tsujikawa T, et al.
  • Journal Title: Journal of Computer Assisted Tomography 33 Pages: 877-881
  • Peer Reviewed
• [Journal Article] Vasodilatory effect of adenosine triphosphate does not change cerebral blood flow : a PET study with ^<15>O-water (2009)
  • Author(s): Hussain R, et al.
  • Journal Title: Annals of Nuclear Medicine 23 Pages: 717-723
  • Peer Reviewed
• [Journal Article] Validation of the calculation of the clearance rate constant (k_<mono>) of [^<11>C]acetate using parametric k_<mono> image for myocardial oxidative metabolism (2009)
  • Author(s): Hussain R, et al.
  • Journal Title: Nuclear Medicine and Biology 36 Pages: 877-882
  • Peer Reviewed
• [Journal Article] Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia : the possible function in tumor acetyl-CoA/acetate metabolism (2009)
  • Author(s): Yoshii Y, et al.
  • Journal Title: Cancer Science 100 Pages: 821-827
  • Peer Reviewed
• [Journal Article] Positron emission tomography in ovarian cancer : 18F-deoxy-glucose and 16-18F-fluoro-17ss-estradiol PET (2009)
  • Author(s): Yoshida Y, et al.
  • Journal Title: Journal of Ovarian Research 2 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Pathophysiologic imaging of uterine tumors with 16α-[18F]fluoro-17 β-estradiol and FDG-PET - Initial experience. (2008)
  • Author(s): Tsujikawa T, Yoshida Y, Mori T, Kurokawa T, Fujibayashi Y, Kotsuji F, Okazawa H.
  • Journal Title: Radiology 248 Pages: 599-605
  • Peer Reviewed
• [Journal Article] Distinctive FDG and FES accumulation pattern of two tamoxifen treated patients with endometrial hyperplasia. (2008)
  • Author(s): Tsujikawa T, Okazawa H, Yoshida Y, Mori T, Kobayashi M, Tsuchida T, Fujibayashi Y.
  • Journal Title: Ann Nucl Med. 22 Pages: 73-77
  • NAID: 10021280213
  • Peer Reviewed
• [Journal Article] Does partial volume corrected maximum SUV based on count recovery coefficient in 3D-PET/CT correlate with clinical aggressiveness of non-Hodgkin lymphoma ? (2008)
  • Author(s): Tsujikawa T, Otsuka H, Morita N, Saegusa H, Kobayashi M, Okazawa H, Nishitani H.
  • Journal Title: Ann Nucl Med. 22 Pages: 23-30
  • Peer Reviewed
• [Journal Article] Comparison of 18F-FDG PET and MRI in Assessment of Uterine Smooth Muscle Tumors. (2008)
  • Author(s): Yoshida Y, Kurokawa T, Sawamura Y, Shinagawa A, Tsujikawa T, Okazawa H, Tsuchida T, Imamura Y, Suganuma N, Kotsuji F.
  • Journal Title: J Nucl Med. 49 Pages: 708-712
  • Peer Reviewed
• [Journal Article] Grading of brain glioma with 11C-acetate PET: comparison with 18F-FDG PET. (2008)
  • Author(s): Tsuchida T, Takeuchi H, Okazawa H, Tsujikawa T, Fujibayashi Y.
  • Journal Title: Nucl Med Biol. 35 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Reproducibility of semi-quantitative parameters in FDG-PET using two different PET scanners: Influence of attenuation correction method and examination interval. (2008)
  • Author(s): Kamibayashi T, Tsuchida T, Demura Y, Tsujikawa T, Okazawa H.
  • Journal Title: Mol Imaging Biol. 10 Pages: 162-166
  • NAID: 120001493896
  • Peer Reviewed
• [Journal Article] Shorter Examination Method for the Diagnosis of Misery Perfusion with Count-Based Oxygen Extraction Fraction Elecation in 15O-Gas PET. (2008)
  • Author(s): Kobayashi M, Kudo T, Tsujikawa T, Isozaki M, Arai Y, Fujibayashi Y, Okazawa H.
  • Journal Title: J Nucl Med. 49 Pages: 242-246
  • Peer Reviewed
• [Journal Article] Uterine Tumors : Pathophysiologic Imaging with 16α-[^<18>F]fluoro-17β-estradiol and ^<18>F Fluorodeoxyglucose PET -Initial Exnerience (2008)
  • Author(s): Tetsuya Tsujikawa, et.al.
  • Journal Title: Radiology 248 Pages: 599-605
  • Peer Reviewed
• [Journal Article] Comparison of ^<18>F-FDG PET and MRI in Assessment of Uterine Smooth Muscle Tumors (2008)
  • Author(s): Yoshio Yoshida, et.al.
  • Journal Title: The Journal of Nuclear Medicine 49 Pages: 708-712
  • Peer Reviewed
• [Journal Article] Grading of brain glioma with ^<11>C-acetate PET : comparison with ^<18>F-FDG PET (2008)
  • Author(s): Tatsuro Tsuchida, et.al.
  • Journal Title: Nuclear Medicine and Biology 35 Pages: 171-176
  • Peer Reviewed
• [Presentation] Functional images reflect aggressiveness of endometrial carcinoma Estrogen receptor expression combined with FDG-PET (2009)
  • Author(s): 辻川哲也
  • Organizer: 第6回日本核医学会最優秀研究奨励賞
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-01
• [Presentation] Functional estrogen receptorαimaging PET with 16α-[18F]-fluoro-17 β-estradiol in endometrial carcinoma. (2009)
  • Author(s): Tsujikawa T, Yoneda M, Yoshida Y, Kudo T, Kurokawa T, Kiyono Y, Fujibayashi Y, Okazawa H.
  • Organizer: The Society of Nuclear Medicine, annual meeting 2009
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2009-06-15
• [Presentation] Functional Estrogen Receptor a imaging PET with 16α-[18F]fluoro-17ss-estradiol in endometrial carcinoma (2009)
  • Author(s): Tsujikawa T
  • Organizer: Society of Nuclear Medicine 2009 Annual Meeting
  • Place of Presentation: Tronto
  • Year and Date: 2009-06-15
• [Presentation] 子宮内膜癌におけるFES集積とホルモン受容体密度の関連 (2009)
  • Author(s): 辻川哲也
  • Organizer: 第68回日本医学放射線学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-17
• [Presentation] 16α-[18F]-fluoro-17 β-estradiol PET is useful for non-invasive Estrogen Receptor a imaging in endometrial carcinoma. (2008)
  • Author(s): Tsujikawa T, Kudo T, Yoshida Y, Kiyono Y, Kobayashi M, Fujibayashi Y, Okazawa H.
  • Organizer: World Molecular Imaging Congress 2008
  • Place of Presentation: Nice, France
  • Year and Date: 2008-09-18
• [Presentation] FES and FDG-PET imaging reflects clinical and histopathological findings in patients with endometrial carcinoma (2008)
  • Author(s): Tetsuya tsujikawa, et.al.
  • Organizer: 55th Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: New Orleans (USA)
  • Year and Date: 2008-06-17
• [Presentation] FES and FDG-PET imaging reflects clinical and histopathological findings in patients with endometrial carcinoma. (2008)
  • Author(s): Tsujikawa T, Kudo T, Yoshida Y, Kiyono Y, Kobayashi M, Tsuchida T, Fujibayashi Y, Okazawa H.
  • Organizer: The Society of Nuclear Medicine, annual meeting 2008
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2008-06-16