Computer-aided diagnosis for differential diagnosis of lacunar infarct

• Project/Area Number: 20790888
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Gifu University
• Principal Investigator: UCHIYAMA Yoshikazu Gifu University, 大学院・医学系研究科, 准教授 (50325172)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 医用画像工学 / コンピュータ支援診断 / ラクナ梗塞 / MR画像 / Magnetic Resonance Imaging

Research Abstract

The detection of asymptomatic lacunar infarcts on MR images is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification of lacunar infarcts is often hard for radiologists because of the difficulty in distinguishing lacunar infarcts and enlarged Virchow-Robin (VR) spaces. Thus, the purpose of this study was to develop a computer-aided diagnosis (CAD) scheme for the detection of lacunar infarcts. This study showed following useful results. (1) We developed a method for classification of lacunar infarcts and VR spaces. Image features, such as, size, shape, and signal intensity, were determined from the segmented lesions. A neural network with image features was employed for distinguishing between lacunar infarcts and enlarged VR spaces. The result obtained from 109 patients indicated that the area under the ROC curve was 0.945. (2) We developed a method for making a fusion image of T2-weighted image and MRA image. The blood flow obtained from MRA was superimposed on the lesion in T2-weighted image. Blood flow on the lesion was a crucial piece of information for the diagnosis of VR spaces. Our CAD scheme would be useful in assisting radiologists for the detection of lacunar infarcts in MR images.

Research Products

• [Journal Article] 脳MR画像におけるラクナ梗塞と血管周囲腔拡大の鑑別法 (2009)
  • Author(s): 國枝琢也, 内山良一, 原武史, 藤田広志, 加藤博基, 浅野隆彦, 兼松雅之, 星博昭, 岩間亨, 紀ノ定保臣, 横山和俊, 篠田淳
  • Journal Title: 医用画像情報学会 Vol.26,No.3 Pages: 59-63
  • NAID: 130000138571
  • Peer Reviewed
• [Journal Article] CAD Scheme for differential diagnosis of lacunar infarcts and normal Virchow-Robin spaces on brain MR images (2009)
  • Author(s): Y. Uchiyama, T. Asano, T. Hara, H. Fujita, H. Hoshi, T. Iwama, Y. Kinosada
  • Journal Title: IFMBE Proceedings Vo.25/V Pages: 126-128
  • Peer Reviewed
• [Journal Article] 脳MR画像におけるラクナ梗塞と血管周囲腔拡大の鑑別法 (2009)
  • Author(s): 國枝琢也, 内山良一, 原武史, 他
  • Journal Title: 医用画像情報学会 26(3) Pages: 59-63
  • NAID: 130000138571
  • Peer Reviewed
• [Journal Article] CAD Scheme for differential diagnosis of lacunar infarcts and normal Virchow-Robin spaces on brain MR images (2009)
  • Author(s): Y.Uchiyama, T.Asano, T.Hara, et al.
  • Journal Title: IFMBE Proceedings 25/V Pages: 126-128
• [Journal Article] Computer-Aided Diagnosis Scheme for Classification of Lacunar Infarcts and Enlarged Virchow-Robin Spaces in Brain MR Images (2008)
  • Author(s): Y. Uchiyama, T. Kunieda, T. Asano, H. Kato, T. Hara, M. Kenematsu, T. Iwama, H. Hoshi, Y. Kinosada, H. Fujita
  • Journal Title: Proc. of the IEEE Engineering In Medicine and Biology Society Vol.1 Pages: 3908-3911
  • Peer Reviewed
• [Journal Article] Computer-Aided Diagnosis Scheme for Classification of Lacunar Infarcts and Enlarged Virchow-Robin Spaces in Brain MR Images (2008)
  • Author(s): Y. Uchiyama, T. Kunieda, T. Asano, et.al.
  • Journal Title: Proc. of the IEEE Engineering In Medicine and Biology Society 1 Pages: 3908-3911
  • Peer Reviewed
• [Presentation] Visible Human画像を用いたラクナ梗塞と血管周囲腔拡大の分類法 (2010)
  • Author(s): 鈴木鷹也, 内山良一, 原武史, 福岡大輔, 岩間亨, 星博昭, 紀ノ定保臣, 藤田広志
  • Organizer: 医用画像研究会
  • Place of Presentation: 沖縄
  • Year and Date: 2010-01-29
• [Presentation] Visible Human画像を用いたラクナ梗塞と血管周囲腔拡大の鑑別法 (2010)
  • Author(s): 鈴木鷹也, 内山良一, 原武史, 他
  • Organizer: 電子情報通信学会 医用画像研究会
  • Place of Presentation: 沖縄
  • Year and Date: 2010-01-29
• [Presentation] Computer-Aided Diagnosis for Detection and Classification of Lacunar Infarcts and Enlarged Virchow Robin Spaces on Brain MR Images (2009)
  • Author(s): Y. Uchiyama, T. Hara, H. Fujita, H. Hoshi, T. Iwama, Y. Kinosada
  • Organizer: Radiological Society of North America (RSNA) Scientific Assembly and Annual Meeting Program
  • Place of Presentation: Chicago
  • Year and Date: 2009-11-29
• [Presentation] Computer-aided diagnosis for detection and classification of lacunar infarcts and enlarged Virchow-Robin spaces on brain MR images (2009)
  • Author(s): Y.Uchiyama, T.Hara, H.Fujita, et al.
  • Organizer: Radiological Society of North America (RSNA) Scientific Assembly and Annual Meeting Program
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-11-29
• [Presentation] ラクナ梗塞の鑑別のためのコンピュータ支援診断システム (2009)
  • Author(s): 内山良一, 原武史, 藤田広志, 岩間亨, 星博昭, 紀ノ定保臣
  • Organizer: 第155回医用画像情報学会大会
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-10-03
• [Presentation] ラクナ梗塞の鑑別のためのコンピュータ支援診断システム (2009)
  • Author(s): 内山良一, 原武史, 藤田広志, 他
  • Organizer: 医用画像情報学会(第155回大会)
  • Place of Presentation: 熊本
  • Year and Date: 2009-10-03
• [Presentation] CAD Scheme for Distinction Between Lacunar Infarcts and Enlarged Virchow-Robin Spaces (2009)
  • Author(s): Y. Uchiyama, T. Kunieda, T. Asano, H. Kato, T. Hara, M. Kanematsu, T. Iwama, H. Hoshi, Y. Kinosada, H. Fujita
  • Organizer: International Forum on Medical Imaging in Asia
  • Place of Presentation: National Taipei University
  • Year and Date: 2009-01-20
• [Presentation] CAD Scheme for Distinction Between Lacunar Infarcts and Enlarged Virchow-Robin Spaces (2009)
  • Author(s): Y. Uchiyama, T. Kunieda, T. Asano, et.al.
  • Organizer: International Forum on Medical Imaging in Asia 2009
  • Place of Presentation: National Taipei University (Taiwan)
  • Year and Date: 2009-01-20
• [Presentation] CAD Scheme for Classification of Slicet Lacunar Infarcts and Enlarged Virchow-Robin Spaces in Brain MR Images (2008)
  • Author(s): Y. Uchiyama, H. Fujita, M. Kanematsu, H. Hoshi, T. Iwama, Y. Kinosada, T. Hara, T. Asano, H. Kato
  • Organizer: Radiological Society of North America (RSNA) Scientific Assembly and Annual Meeting Program
  • Place of Presentation: Chicago
  • Year and Date: 2008-12-05
• [Presentation] 脳MR画像におけるラクナ梗塞と血管周囲腔拡大の鑑別法 (2008)
  • Author(s): 國枝琢也, 内山良一, 原武史, 藤田広志, 加藤博基, 浅野隆彦, 星博昭, 兼松雅之, 山川弘保, 安藤弘道, 岩間亨
  • Organizer: 第27回日本医用画像工学会大会
  • Place of Presentation: 法政大学
  • Year and Date: 2008-08-05