| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Tumor hypoxia is critically important in tumor physiology and cancer treatment, and it appears to be strongly associated with malignant progression and therapy resistance. Thus, it has been desired to investigate variations in tumor hypoxia. Here, to develop a method to estimate oxygen metabolism in tumors by PET, we constituted ^15O-O_2 gas supplying system for rats, clarified that tumor blood flow depended on their weights, and performed the estimation of myocardial oxygen metabolism in pigs by ^15O-O_2 gas inhalation method. In addition, to visualize biological hypoxia regions in tumors, we developed a molecular probe composed mainly of oxygen dependent degradation domain of HIF-1 and radiolabeling moiety, and succeeded in in vivo tumor imaging with pre-targeting method by PET.
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