The ^<17>O MRS/MRI for the tumor oxygen consumption rate in mice

Research Project

Project/Area Number	20790893
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	Kyoto University
Principal Investigator	NARAZAKI Michiko Kyoto University, 大学院・情報学研究科, 特定研究員(科学技術振興) (10467459)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	核磁気共鳴画像(MRI) / 多核種 / 酸素代謝
Research Abstract	The tumor oxygen consumption rate in tumor-bearing mice using ^<17>O MRS/MRI was investigated based on the metabolically generated ^<17>O-water from ^<17>O2 gas. ^<17>O images were acquired before and after the inhalation of ^<17>O enriched oxygen gas. The increment in the ^<17>O image intensity due to the metabolically generated H2^<17>O from ^<17>O2 was converted to the quantity of produced H2^<17>O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.

Report

(3 results)