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Evaluation of [C-11]benzyl acetate as a marker of glial metabolism

Research Project

Project/Area Number 20790895
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

MOMOSAKI Sotaro  Osaka University, 大学院・医学系研究科, 助教 (30379268)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsベンジルアセテート / グリア代謝 / 脳内動態 / PET / ラット
Research Abstract

As a marker of glial metabolism, [<11>^C]benzyl acetate ([<11>^C]BA) was synthesized and evaluated in living rat brain using positron emission tomography (PET). We succeed the synthesis of [<11>^C]BA, the measurement of distribution in the living rat brain and the kinetic analysis in this study. The results show that [<11>^C]BA is a good candidate for the measurement of glial metabolism.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (11 results)

  • [Journal Article] Role of NMDA receptor upon [14C]acetate uptake into intact rat brain.2009

    • Author(s)
      Hirose S, Momosaki S, Hosoi R, Abe K, Gee A, Inoue O.
    • Journal Title

      Ann Nucl Med. 23(2)

      Pages: 143-7

    • NAID

      10025135668

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] De-coupling of blood flow and metabolism in the rat brain induced by glutamate.2009

    • Author(s)
      Hirose S, Momosaki S, Sasaki K, Hosoi R, Abe K, Gee A, Inoue O.
    • Journal Title

      Ann Nucl Med. 23(3)

      Pages: 293-300

    • NAID

      10025136159

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] De-coupling of blood flow and metabolism in the rat brain induced by glutamate.2009

    • Author(s)
      Hirose S
    • Journal Title

      Ann Nucl Med. 23(3)

      Pages: 293-300

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of NMDA receptor upon [^<14>C]acetate uptake into intact rat brain2008

    • Author(s)
      Hirose S
    • Journal Title

      Ann Nucl Med 23(2)

      Pages: 143-147

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 半導体PETカメラ(Sumitomo MIP-100)によるマウス脳の糖代謝イメージング2009

    • Author(s)
      桃崎壮太郎, 他
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-02
    • Related Report
      2009 Final Research Report
  • [Presentation] メチルエチルケトンによる痙攣発作抑制作用と糖代謝画像2009

    • Author(s)
      桃崎壮太郎, 他
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative assessment of regional glucose metabolism in normal rats using semiconductor animal PET.2009

    • Author(s)
      Takasawa M, Momosaki S, et al.
    • Organizer
      Society of Nuclear Medicine 56th Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2009-06-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Performance evaluation of a newly developed semiconductor small animal PET scanner Sumitomo MIP-100.2009

    • Author(s)
      Yamazaki Y, Murase K, Momosaki S, et al.
    • Organizer
      Society of Nuclear Medicine 56th Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2009-06-15
    • Related Report
      2009 Final Research Report
  • [Presentation] [F-18]FDG imaging of mice brain using a high resolution semiconductor PET camera (Sumitomo MIP-100)2009

    • Author(s)
      S Momosaki
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantitative assessment of regional glucose metabolism in normal rats using semiconductor animal PET2009

    • Author(s)
      M Takasawa
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Performance evaluation of a newly developed semiconductor small animal PET scanner Sumitomo MIP-1002009

    • Author(s)
      Y Yamazaki
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2009-06-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] グルタミン酸注入による神経障害時の脳循環・代謝に関する検討2009

    • Author(s)
      桃崎壮太郎, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] [F-18]FDG imaging of mice brain using a high resolution semiconductor PET camera (Sumitomo MIP-100).2009

    • Author(s)
      Momosaki S, et al.
    • Organizer
      Society of Nuclear Medicine 56th Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] 病態モデルラット脳における[14C]Benzyl acetateの取り込みに関する検討2008

    • Author(s)
      桃崎壮太郎, 他
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 病態モデルラット脳における[^<14>C]Benzyl acetateの取り込みに関する検討2008

    • Author(s)
      桃崎壮太郎
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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