Combined <11>^C-Choline PET with high-resolution MRI : Development for T- and N-Stage Assessment in Patients with Prostate Cancer.
| Project/Area Number |
20790897
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
MAEDA Tetsuo Kobe University, 医学部附属病院, 特命講師 (00457095)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 前立腺がん / コリンPET / MRI |
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| Research Abstract |
We evaluated the preliminary result of combined <11>^C-choline PET and CT or MRI for T- and N-stage assessments in candidates for radical prostatectomy due to biopsy-proven prostatic cancer. Thirty-four pathologically diagnosed prostate cancer patients prospectively underwent <11>^C-choline PET, unenhanced whole-body MDCT and pelvic MRI prior to surgical resection. Then, a board-certified radiologist and a nuclear medicine physician assessed T- and N-stage in each patient on combined PET with CT or MRI (combined PET-CT/MRI), and final diagnosis in each patient was made by consensus of two readers. When all images were evaluated, readers were unaware of any clinical information and histological results. Then, assessed T- and N-stage in each patient were compared with each T- and N-stages based on pathological results, and diagnostic tendency were determined. Thirty-two cases underwent radical prostatectomies, and two cases were underwent exploratory laparotomies due to a detection of pelvic lymph nodes metastases. Postoperative T staging were pT2b (n=13), pT3a (n=8), pT3b (n=1), and pT4 (n=10). On T-stage assessment, combined PET-CT/MRI could correctly diagnose in all patients with pT2b and pT3a, whereas this method could not correctly diagnose in patients with pT3b and pT4. On N-stage assessment, all lymph node metastases, whose short axis diameters were more than 7mm, were correctly diagnosed on combined PET-CT/MRI. Our preliminary result suggests that combined PET-CT/MRI might be useful for T- and N-stage assessments in patients with prostatic cancer. We presented the result on 12^<th> Asian Oceanian Congress of Radiology. Further studies are needed to clarify the usefulness of this method.
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Report
(3 results)
Research Products
(7 results)
