The local gene transfer for prevention of deep vein thrombosis

• Project/Area Number: 20790901
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Miyazaki
• Principal Investigator: FURUKOUJI Eiji University of Miyazaki, 医学部, 助教 (00423723)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 深部静脈血栓症 / 遺伝子導入 / 静脈 / vWF-CP / ADAMTS13

Research Abstract

Anticoagulation is the usual treatment for deep vein thrombosis. But excessive or spontaneous bleeding may be a side effect of anticoagulation. The present study examines whether vWF-CP suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to venous wall. Conclusion; The local expression of vWF-CP in rat inferior vena cava might prevent venous thrombosis.