Project/Area Number |
20790903
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Tokyo Metropolitan University |
Principal Investigator |
NUMANO Tomokazu Tokyo Metropolitan University, 人間健康科学研究科, 助教 (10399511)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 核磁気共鳴画像(MRI) / 拡散強調画像(DWI) / Magnetic resonance imaging : MRI / Diffusion weighted imaging : DWI / Three-dimensional imaging / MP-RAGE法 / Tubo-FLASH法 / Three-dimensional DWI / CHESS法 / 水励起法 / Turbo-FLASH法 |
Research Abstract |
The purpose of this study was to develop a novel technique for fat-saturated three-dimensional (3D) diffusion-weighted (DW) MRI sequencing based upon the 3D magnetization-prepared rapid gradient-echo (3D-MP-RAGE) method. In order to saturate fat, two kinds of techniques were composed: the FatSat-3D-DWI sequence and WE-3D-DWI sequence, "chemical shift selective: CHESS (FatSat) method vs water excitation: WE method". The FatSat-3D-DWI sequence and WE-3D-DWI sequence were compared in terms of their degree of fat suppression. In the FatSat-3D-DWI sequence, the preparation phase with a "CHESS-90oRF-motion probing gradient : MPG-180oRF-MPG-90oRF" pulse-train was used to sensitize the magnetization to fat-saturated diffusion. In contrast, in the WE-3D-DWI sequence, a RAGE-excitation pulse with a "binominal-pulse 1-1 or 1-2-1" was selected for water-excited (fat-saturated) diffusion imaging. From experimental results obtained with a phantom, the effect of diffusion weighting and the effect of fat-saturation were confirmed. Fat saturation was much better in the WE-3D-DWI sequence than the CHESS-3D-DWI sequence. From animal (rat pelvis) experimental results using WE-3D-DWI, fat-saturated diffusion-weighted image data were obtained. This sequence was useful for in vivo imaging.
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