Targeting adhesion molecule integrin signal transduction for improving radiation therapeutic gain

• Project/Area Number: 20790910
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: OGATA Toshiyuki Osaka University, 医学系研究科, 特任助教(常勤) (90460576)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インテグリン / 放射線 / 転移 / 浸潤 / integrin linked kinase

Research Abstract

The purpose of this study is to investigate targeting adhesion molecule integrin signal transduction as improving radiation therapeutic gain. We confirmed that inhibition of integrin linked kinase, a receptor-proximal effecter of integrin, resulted in a marked reduction of radiation-induced invasion of cancer cells. Thus, blocking the integrin signal pathway is a highly promising approach to enhancing the efficacy of radiation.

Research Products

• [Journal Article] Recent advances in the biology of heavy-ion cancer therapy. (2010)
  • Author(s): Hamada N, Imaoka T, Masunaga S, Ogata T, Okayasu R, Takahashi A, Kato TA, Kobayashi Y, Ohnishi T, Ono K, Shimada Y, Teshima T.
  • Journal Title: J Radiat Res 51 Pages: 365-383
  • NAID: 10026563608
  • Peer Reviewed
• [Journal Article] Recent advances in the biology of heavy-ion cancer therapy. (2010)
  • Author(s): 浜田信行、尾方俊至, 他
  • Journal Title: Journal of Radiation Research Volume: 51 Pages: 365-383
  • NAID: 10026563608
  • Peer Reviewed
• [Journal Article] Early administration of IL-6RA does not prevent radiation-induced lung injury in mice. (2010)
  • Author(s): 尾方俊至
  • Journal Title: Radiation Oncology Volume: 5
  • Peer Reviewed
• [Journal Article] 光子線と重粒子線によるがんの転移過程と血管新生に及ぼす影響 (2009)
  • Author(s): 尾方俊至、手島昭樹、松浦成昭
  • Journal Title: 特集(重粒子線治療生物学の進展):総説放射線生物研究 44 Pages: 199-207
  • NAID: 130006999721
• [Journal Article] Verification of air-kerma strength of 125I seed for permanent prostate implants in Japan. (2009)
  • Author(s): 隅田伊織
  • Journal Title: Int J Clin Oncol. 14 Pages: 525-528
  • Peer Reviewed
• [Journal Article] Carbon ion irradiation suppresses metastatic potential of human non-small cell lung cancer A549 cells through the phosphatidylinositol -3-kinase/Akt signaling pathway.
  • Author(s): Ogata T, Teshima T, Inaoka M, Minami K, suchiya T, Isono M, Furusawa Y, Matsuura N.
  • Journal Title: J Radiat Res (in press.)
  • NAID: 10028111518
  • Peer Reviewed
• [Journal Article] Carbon ion irradiation suppresses metastatic potential of human non-small cell lung cancer A549 cells through the Phosphatidylinositol-3-kinase/Akt signaling pathway.
  • Author(s): 尾方俊至
  • Journal Title: Journal of Radiation Research Volume: (掲載確定)
  • NAID: 10028111518
  • Peer Reviewed
• [Presentation] 子宮頸癌術後照射におけるIMRT治療計画の基礎的検討 (2010)
  • Author(s): 尾方俊至
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-19
• [Presentation] EPIDを用いたMLCの経時的位置精度の基礎的検討 (2010)
  • Author(s): 尾方俊至
  • Organizer: 第99回日本医学物理学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-10
• [Presentation] 阪大医学物理室における品質管理体制の現状と今後について (2009)
  • Author(s): 尾方俊至
  • Organizer: 日本医学放射線学会第293回関西地方会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-17
• [Presentation] 前立腺IMRT治療計画におけるマージンサイズの基礎的検討 (2009)
  • Author(s): 尾方俊至
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-18
• [Presentation] 二次元半導体検出器を用いたバーチャルウエッジの週間出力検証 (2009)
  • Author(s): 尾方俊至
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-18
• [Presentation] 光子線と重粒子線によるがんの転移過程と血管新生に及ぼす影響 (2008)
  • Author(s): 尾方俊至
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2008-11-19
• [Book] 放射線生物研究 (2009)
  • Author(s): 尾方俊至
  • Total Pages: 116
  • Publisher: 放射線生物研究会