Targeting adhesion molecule integrin signal transduction for improving radiation therapeutic gain
| Project/Area Number |
20790910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
OGATA Toshiyuki Osaka University, 医学系研究科, 特任助教(常勤) (90460576)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インテグリン / 放射線 / 転移 / 浸潤 / integrin linked kinase |
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| Research Abstract |
The purpose of this study is to investigate targeting adhesion molecule integrin signal transduction as improving radiation therapeutic gain. We confirmed that inhibition of integrin linked kinase, a receptor-proximal effecter of integrin, resulted in a marked reduction of radiation-induced invasion of cancer cells. Thus, blocking the integrin signal pathway is a highly promising approach to enhancing the efficacy of radiation.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Recent advances in the biology of heavy-ion cancer therapy.2010
Author(s)
Hamada N, Imaoka T, Masunaga S, Ogata T, Okayasu R, Takahashi A, Kato TA, Kobayashi Y, Ohnishi T, Ono K, Shimada Y, Teshima T.
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Journal Title
J Radiat Res 51
Pages: 365-383
NAID
Related Report
Peer Reviewed
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