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Targeting adhesion molecule integrin signal transduction for improving radiation therapeutic gain

Research Project

Project/Area Number 20790910
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

OGATA Toshiyuki  Osaka University, 医学系研究科, 特任助教(常勤) (90460576)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsインテグリン / 放射線 / 転移 / 浸潤 / integrin linked kinase
Research Abstract

The purpose of this study is to investigate targeting adhesion molecule integrin signal transduction as improving radiation therapeutic gain. We confirmed that inhibition of integrin linked kinase, a receptor-proximal effecter of integrin, resulted in a marked reduction of radiation-induced invasion of cancer cells. Thus, blocking the integrin signal pathway is a highly promising approach to enhancing the efficacy of radiation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Recent advances in the biology of heavy-ion cancer therapy.2010

    • Author(s)
      Hamada N, Imaoka T, Masunaga S, Ogata T, Okayasu R, Takahashi A, Kato TA, Kobayashi Y, Ohnishi T, Ono K, Shimada Y, Teshima T.
    • Journal Title

      J Radiat Res 51

      Pages: 365-383

    • NAID

      10026563608

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in the biology of heavy-ion cancer therapy.2010

    • Author(s)
      浜田信行、尾方俊至, 他
    • Journal Title

      Journal of Radiation Research

      Volume: 51 Pages: 365-383

    • NAID

      10026563608

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early administration of IL-6RA does not prevent radiation-induced lung injury in mice.2010

    • Author(s)
      尾方俊至
    • Journal Title

      Radiation Oncology

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 光子線と重粒子線によるがんの転移過程と血管新生に及ぼす影響2009

    • Author(s)
      尾方俊至、手島昭樹、松浦成昭
    • Journal Title

      特集(重粒子線治療生物学の進展):総説放射線生物研究 44

      Pages: 199-207

    • NAID

      130006999721

    • Related Report
      2010 Final Research Report
  • [Journal Article] Verification of air-kerma strength of 125I seed for permanent prostate implants in Japan.2009

    • Author(s)
      隅田伊織
    • Journal Title

      Int J Clin Oncol. 14

      Pages: 525-528

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon ion irradiation suppresses metastatic potential of human non-small cell lung cancer A549 cells through the phosphatidylinositol -3-kinase/Akt signaling pathway.

    • Author(s)
      Ogata T, Teshima T, Inaoka M, Minami K, suchiya T, Isono M, Furusawa Y, Matsuura N.
    • Journal Title

      J Radiat Res (in press.)

    • NAID

      10028111518

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbon ion irradiation suppresses metastatic potential of human non-small cell lung cancer A549 cells through the Phosphatidylinositol-3-kinase/Akt signaling pathway.

    • Author(s)
      尾方俊至
    • Journal Title

      Journal of Radiation Research

      Volume: (掲載確定)

    • NAID

      10028111518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮頸癌術後照射におけるIMRT治療計画の基礎的検討2010

    • Author(s)
      尾方俊至
    • Organizer
      日本放射線腫瘍学会第23回学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] EPIDを用いたMLCの経時的位置精度の基礎的検討2010

    • Author(s)
      尾方俊至
    • Organizer
      第99回日本医学物理学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 阪大医学物理室における品質管理体制の現状と今後について2009

    • Author(s)
      尾方俊至
    • Organizer
      日本医学放射線学会第293回関西地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前立腺IMRT治療計画におけるマージンサイズの基礎的検討2009

    • Author(s)
      尾方俊至
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二次元半導体検出器を用いたバーチャルウエッジの週間出力検証2009

    • Author(s)
      尾方俊至
    • Organizer
      第97回日本医学物理学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光子線と重粒子線によるがんの転移過程と血管新生に及ぼす影響2008

    • Author(s)
      尾方俊至
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2008-11-19
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Book] 放射線生物研究2009

    • Author(s)
      尾方俊至
    • Total Pages
      116
    • Publisher
      放射線生物研究会
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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