A study of the axonal diameter based on the restricted water diffusion using MRI

• Project/Area Number: 20790918
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Central Institute for Experimental Animals
• Principal Investigator: HIKISHIMA Keigo Central Institute for Experimental Animals, 病理病態研究部, 研究員 (30420219)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 磁気共鳴画像(MRI) / MRI / 拡散 / q-space

Research Abstract

Diffusion magnetic resonance imaging (MRI) enables us to observe the restricted water mobility resulted from various microstructure in vivo. We developed an analysis of the axonal diameter using q-space diffusion MRI. This new method could be powerful tool for monitoring pathological conditions in clinical practice.

Research Products

• [Journal Article] 高分解能High b-value多軸拡散計測による視交叉神経走行追跡 (2009)
  • Author(s): 疋島啓吾、山田雅之、藤吉兼浩、百島祐貴、川井健司、中村雅也、玉置憲一、岡野栄之
  • Journal Title: 日本磁気共鳴医学会雑誌 29巻、1号 Pages: 41-44
  • NAID: 10026287417
  • Peer Reviewed
• [Journal Article] 高分解能High b-Value多軸拡散計測による視交叉神経走行追跡 (2009)
  • Author(s): 疋島啓吾
  • Journal Title: 高分解能High b-Value多軸拡散計測による視交叉神経走行追跡 29 Pages: 41-44
  • NAID: 10026287417
• [Presentation] q-spaceから見える組織構造 (2009)
  • Author(s): 疋島啓吾
  • Organizer: 第一回q-space研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] q-space imagingを用いたmyelinの可視化 (2009)
  • Author(s): 疋島啓吾、藤吉兼浩、山田雅之、小牧裕司、百島祐貴、八木一夫、玉置憲一、戸山芳昭、中村雅也、岡野栄之
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] q-spaceから見える組織構造 (2009)
  • Author(s): 疋島啓吾
  • Organizer: 日本磁気共鳴医学会大会 第一回q-space研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 高空間・高角度分解能拡散計測による視交叉神経走行の解析 (2008)
  • Author(s): 疋島啓吾、山田雅之、藤吉兼浩、百島祐貴、川井健司、中村雅也、玉置憲一、岡野栄之
  • Organizer: 第36回日本磁気共鳴医学会大会
  • Place of Presentation: 旭川
  • Year and Date: 2008-09-11
• [Presentation] q-space MRIのコモンマーモセット脊髄への適用 (2008)
  • Author(s): 疋島啓吾、中村雅也、藤吉兼浩、山田雅之、北村和也、百島祐貴、八木一夫、玉置憲一、戸山芳昭、岡野栄之
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] In vivo high Resolution q-space imaging of the spinal cord injury in Nonhuman primates (2008)
  • Author(s): K. Hikishima, M. Nakamura, K. Fujiyoshi, M. Yamada, K. Kitamura, S. Momoshima, K. Yagi, N. Tamaoki, Y. Toyama, H. Okano
  • Organizer: 17th Annual Meeting of International Society of Magnetic Resonance in Medicine
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-05-03
• [Presentation] In vivo high resolution q-space imaging Of the spinal cord injury in Nonhuman primates. (2008)
  • Author(s): Keigo Hikishima
  • Organizer: 第17回国際磁気共鳴医学会大会
  • Place of Presentation: トロント(カナダ)