PET Imaging for Assessment of Efficacy of EGFR Kinase Inhibitors
| Project/Area Number |
20790926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
KAGAWA Shinya Research Institute, Shiga Medical Center, 主任研究員 (10393191)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 上皮成長因子 / PET / 画像診断 / 癌 / 分子標的 / PET画像診断 / 国際情報交換 / アメリカ / 上皮成長因子素 |
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| Research Abstract |
The purpose of this study is to assess the efficacy of I-mIPQA PET imaging for prediction of responsiveness to therapy with EGFR kinase inhibitor gefitinib with orthotopic non-small cell lung carcinoma xenograft in mice. Human lung carcinoma cells PC14GL, H441GL, H3255GL, and H1975GL, expressing different EGFR mutants and various levels of TGFα. In vitro uptake study of I-mIPQA with these lung cancer cell lines, biodistribution study of I-mIPQA in tumor bearing mice with or without inhibitor were performed. I-mIPQA PET imaging: 3 and 24 hours imaging post intravenous injection of radiotracer using microPET were also conducted followed by auroradiograpfy (ARG) study of I-mIPQA after PET imaging with or without treatment with Gefitinib (Iressa), for three days after PET imaging. PET with I-mIPQA would be a promising molecular imaging of different EGFR kinase mutant NSCL carcinomas for prediction of responsiveness to EGFR Kinase inhibitors in patients.
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Report
(4 results)
Research Products
(34 results)
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[Presentation] Compared with gene expression levels of amino acid transporter and accumulation of [^<14>C]MeAIB and [^3H]MET in human carcinomas2010
Author(s)
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Fumiya Takahashi, Kazuyo Ohe, Hiroyuki Okudaira, Masato Kobayashi, TomoyaUehara, Yasushi Arano, Keiichi Kawai
Organizer
World Molecular Imaging Congress (WMIC)
Place of Presentation
Kyoto International Conference Center (Kyoto, Japan)
Year and Date
2010-09-10
Related Report
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[Presentation] Characterisation of system A amino acid transport and system L : uptake mechanism of [<14>^C]MeAIB and[3^H]Methionine in human carcinomas2009
Author(s)
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroyo Araki, Hiroyuki Okudaira, Tomoya Uehara, Masato Kobayashi, Mitsuyoshi Yoshimoto, Yasushi Arano, Keiichi Kawai
Organizer
European Association of Nuclear Medicine (EANM) Congress
Place of Presentation
Barcelona, Spain
Year and Date
2009-10-11
Related Report
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