Enhancing effect in the expression of tumor antigens and T-cell sensitivity against tumor cells after treatment with epigenetic drugs.

• Project/Area Number: 20790930
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Shimane University
• Principal Investigator: HARASHIMA Nanae Shimane University, 医学部, 助教 (60345311)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 腫瘍 / 免疫 / エピジェネティクス / 薬剤反応性 / 癌 / 免疫学

Research Abstract

Histone deacetylase inhibitor (HDACi) strikingly induced cell death and decreasing cell viability of the human renal cell carcinoma and prostate cancer cells in dose- and time-dependent manner, although the effect of a DNA methyltransferase inhibitor was not recognized. Moreover, tumor-specific antigens were maintained their gene expression as a target of T-cells which enough recognizes the cancer cells after HDACi treatment.

Research Products

• [Journal Article] Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma. (2010)
  • Author(s): Miki Tongu
  • Journal Title: Cancer Immunology, Immunotherapy 59 Pages: 769-777
  • Peer Reviewed
• [Journal Article] Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma. (2009)
  • Author(s): Tongu M, Harashima N, Yamada T, Harada T, Harada M
  • Journal Title: Cancer Immunol Immunother. 59(5) Pages: 767-777
  • Peer Reviewed
• [Journal Article] Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies. (2009)
  • Author(s): Kondo M, Murakawa Y, Harashima N, Kobayashi S, Yamaguchi S, Harada M
  • Journal Title: Immunology 128
  • Peer Reviewed
• [Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages. (2009)
  • Author(s): Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M
  • Journal Title: Cancer Sci. 100 Pages: 481-489
  • NAID: 10025143429
  • Peer Reviewed
• [Journal Article] Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies. (2009)
  • Author(s): Masahiro Kondo
  • Journal Title: Immunology 128
  • Peer Reviewed
• [Journal Article] Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in pathogenesis of inflammatory myopathies (2009)
  • Author(s): Kondo, M.
  • Journal Title: Immunology (In press)
  • Peer Reviewed
• [Journal Article] ( *These authors contributed equally to this work. ) Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. (2008)
  • Author(s): Takahashi Y*, Harashima N*, Kajigaya S, Yokoyama H, Cherkasova E, McCoy JP, Hanada K, Mena O, Kurlander R, Tawab A, Srinivasan R, Lundqvist A, Malinzak E, Geller N, Lerman MI, Childs RW
  • Journal Title: J Clin Invest. 118 Pages: 1099-1109
  • Peer Reviewed
• [Journal Article] Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells (2008)
  • Author(s): Takahashi, Y., Harashima, N. (eaually contributed)
  • Journal Title: Journal of Clinical Investigation 118 Pages: 1099-1109
  • Peer Reviewed
• [Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in asubgroup of individuals at asymptomatic and smoldering stages (2008)
  • Author(s): Shimizu, Y.
  • Journal Title: Cancer Science 100 Pages: 481-489
  • Peer Reviewed
• [Presentation] TLR3リガンドによる前立腺癌細胞のアポトーシス (2009)
  • Author(s): 原田守
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] TLR3リガンドによる前立腺癌細胞のアポトーシス (2009)
  • Author(s): 原田守
  • Organizer: 第39回 日本免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] TLR3リガンド刺激により誘導されるtype-I IFNを介する前立腺癌細胞の細胞死 (2009)
  • Author(s): 原嶋奈々江
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] TLR3リガンド刺激により誘導されるtype-I IFNを介する前立腺癌細胞の細胞死 (2009)
  • Author(s): 原嶋奈々江
  • Organizer: 第68回 日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-02
• [Presentation] Immunogenic chemotherapy with cyclophosphamide and adriamycin against established murine colon carcinoma. (2009)
  • Author(s): 原田守
  • Organizer: 第13回日本がん免疫学会
  • Place of Presentation: 北九州
  • Year and Date: 2009-06-25
• [Presentation] Immunogenic chemotherapy with cyclophosphamide and adriamycin against established murine colon carcinoma (2009)
  • Author(s): 原田守
  • Organizer: 第13回 日本がん免疫学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-06-25
• [Presentation] 成人T細胞白血病の免疫学的リスクファクター (2008)
  • Author(s): Shimizu, Y.
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 炎症性筋疾患の病態における炎症性サイトカインとFasの役割 (2008)
  • Author(s): 近藤正宏
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 成人T細胞白血病の免疫学的リスクファクター (2008)
  • Author(s): 清水由紀子
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 炎症性筋疾患の病態における炎症性サイトカインとFasの役割 (2008)
  • Author(s): Kondo, M.
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Cyclophosphamideとadriamycinによる抗がん免疫応答の誘導 (2008)
  • Author(s): 頓宮美樹
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識するHERV-E由来新規腫瘍抗原CT-RCCの同定とその発現解析 (2008)
  • Author(s): 高橋義行
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 一部のHTLV-Iキャリアとくすぶり型ATLはTax特異的T細胞応答の減弱と高プロウイルス量を示す (2008)
  • Author(s): 清水由紀子
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Cyclophosphamideとadriamycinによる抗がん免疫応答の誘導 (2008)
  • Author(s): 頓宮美樹
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識するHERV-E由来新規腫瘍抗原CT-RCCの同定とその発現解析 (2008)
  • Author(s): 高橋義行
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 一部のHTLV-Iキャリアとくすぶり型ATLはTax特異的T細胞応答の減弱と高プロウイルス量を示す (2008)
  • Author(s): 清水由紀子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] ATLおよびその前段階におけるTax特異的T細胞の低応答性:免疫学的ATL危険因子とその回避 (2008)
  • Author(s): 神奈木真理
  • Organizer: 第1回HTLV-1研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-24
• [Presentation] ATLおよびその前段階におけるTax特異的T細胞の低応答性 : 免疫学的ATL危険因子とその回避 (2008)
  • Author(s): 神奈木真理
  • Organizer: 第1回HTLV-1研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-24
• [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識する新規腫瘍抗原の同定とその発現解析 (2008)
  • Author(s): 原嶋奈々江
  • Organizer: 第12回基盤的癌免疫研究会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-07-02
• [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識する新規腫瘍抗原の同定とその発現解析 (2008)
  • Author(s): 原嶋奈々江
  • Organizer: 第12回基盤的癌免疫研究会総会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-07-02