| Project/Area Number |
20790936
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
UENO Masaki Wakayama Medical University, 医学部, 助教 (90405465)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 再生医学 / 肝硬変 / 遺伝子治療 / 細胞治療 / Hepatocyte growth factor / 肝再生 / heoatocyte growth factor / hepatocyte growth factor |
|---|
| Research Abstract |
In a cirrhotic liver, the hepatic functional reserve are impaired, therefore administration of hepatectomy are limited. Moreover, in order to elongate the survival outcome, therapeutic strategy against cirrhosis is needed. In this study, we demonstrated the administration of the hepatocyte growth factor (HGF) which were recognized as a promoter of cellular proliferation and as an anti-apoptotic or anti-fibrotic factor for injured tissue to drug inducing cirrhosis model and hepatectomy model and revealed improvement of fibrotic status and survival outcome after hepatectomy.
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