A functional analysis of stabilizing factor BAP1 of cancer-restraining gene BRCA1
Project/Area Number |
20790939
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General surgery
|
Research Institution | St.Marianna University School of Medicine |
Principal Investigator |
NISHIKAWA Hiroyuki St.Marianna University School of Medicine, 医学(系)研究科(研究院), 研究技術員 (90387077)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 癌遺伝子 / 乳癌 / 遺伝子 |
Research Abstract |
BAP1 interacts with BARD1. BAP1 inhibits the E3 ligase activity of BRCA1 by interfering the BRCA1/BARD1 RING heterodimer formation. BAP1 is capable of deubiquitinating BRCA1 autoubiquitinated. BAP1 and BRCA1/BARD1 coordinately regulate ubiquitination during the DNA damage response and the cell cycle.
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Report
(4 results)
Research Products
(6 results)