| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In present study, we established transplant tolerance in orthotropic rat liver transplantation and transplant tolerance was transferred adoptively by peripheral lymphocyte, within regulatory T cells. CD4 (+) T cells or CD8 (+) T cells from peripheral lymphocyte of long term survivor were adoptive transferred to naive rat after cell sorting and we revealed that both groups were able to induce transplant tolerance in rat liver transplantation. These results suggested that regulatory T cells were existed not only in population of CD4 (+) CD25 (+) T cells but in CD8 (+) T cells.
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