| Project/Area Number |
20790948
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
YAMAMOTO Masayoshi Hamamatsu University School of Medicine, 医学部附属病院, 医員 (70397420)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血管新生阻害剤 / 分子標的治療 / 転移 / Premetastatic niche / 併用療法 / 血管新生 / 微小環境 / ケモカイン |
|---|
| Research Abstract |
The aim of this study was to investigate the inhibitory effect of TSU68 on colon cancer liver metastasis, and to establish the optimal administration schedule with TSU68. In animal model of colon cancer liver metastasis, the expression of CXCL1 in premetastatic liver was significantly decreased by TSU68 treatment. In addition, the amount of interleukin-12 (IL-12) p40 in the portal vein was significantly decreased by TSU68 treatment. These results suggest that TSU68 may modulate the pre-metastatic niche in the target organ through suppression of the inflammatory response, which might be an alternative mechanism used by anti-angiogenic agents.
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