The mechanical analysis of angiogenic inhibitor TSU68 for the inhibition of liver metastasis and the decision of optimal administration schedule

• Project/Area Number: 20790948
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: YAMAMOTO Masayoshi Hamamatsu University School of Medicine, 医学部附属病院, 医員 (70397420)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 血管新生阻害剤 / 分子標的治療 / 転移 / Premetastatic niche / 併用療法 / 血管新生 / 微小環境 / ケモカイン

Research Abstract

The aim of this study was to investigate the inhibitory effect of TSU68 on colon cancer liver metastasis, and to establish the optimal administration schedule with TSU68. In animal model of colon cancer liver metastasis, the expression of CXCL1 in premetastatic liver was significantly decreased by TSU68 treatment. In addition, the amount of interleukin-12 (IL-12) p40 in the portal vein was significantly decreased by TSU68 treatment. These results suggest that TSU68 may modulate the pre-metastatic niche in the target organ through suppression of the inflammatory response, which might be an alternative mechanism used by anti-angiogenic agents.

Research Products

• [Journal Article] TSU68 Prevents Liver Metastasis of Colon Cancer Xenografts by Modulating the Premetastatic Niche (2008)
  • Author(s): Yamamoto, Hirotoshi Kikuchi, Manabu Ohta, Toshiki Kawabata, Yoshihiro Hiramatsu, Kenji Kondo, Megumi Baba, Kinji Kamiya, Tatsuo Tanaka, Masatoshi Kitagawa, Hiroyuki Konno
  • Journal Title: Cancer Research 68 Pages: 9754-62
  • Peer Reviewed
• [Journal Article] TSU68 Prevents Liver Metastasis of Colon Cancer Xenografts by Modulating the Premetastatic Niche (2008)
  • Author(s): 山本真義
  • Journal Title: Cancer Research 68 Pages: 9754-9762
  • Peer Reviewed
• [Presentation] TSU68 prevents liver metastasis of colon cancer xenografts by modulating the pre-metastatic niche (2009)
  • Author(s): Masayoshi Yamamoto
  • Organizer: 100th American Association of Cancer Research
  • Place of Presentation: Colorado Conventional Center
  • Year and Date: 2009-04-20
• [Presentation] 大腸癌肝転移におけるCXCL1/CXCR2の関与および血管新生阻害剤TSU68による肝転移制御メカニズム解明 (2009)
  • Author(s): 山本真義
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-04-02
• [Presentation] 大腸癌肝転移におけるCXCL1/CXCR2の関与および血管新生阻害剤TSU68による肝転移制御メカニズムの解明 (2009)
  • Author(s): 山本真義
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡国際会議場
• [Presentation] TSU68 Prevents Liver Metastasis of Colon Cancer Xenografts by Modulating the Premetastatic Niche (2008)
  • Author(s): 山本真義
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] TSU68 prevents liver metastasis of colon cancer xenografts by modulating the pre-metastatic niche (2008)
  • Author(s): 山本真義
  • Organizer: 第67回日本癌学会定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] 血管新生阻害剤TSU68による肝転移抑制メカニズムの解析 (2008)
  • Author(s): 山本真義
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2008-05-16
• [Presentation] he role of angiogenic inhibitor TSU68 for the prevention of colon cancer liver metastasis (2008)
  • Author(s): Masayoshi Yamamoto
  • Organizer: 99th American Association of Cancer Research
  • Place of Presentation: San Diego Conventional Center
  • Year and Date: 2008-04-15