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Research on improving safety of living donor liver transplantation using small-for-size graft

Research Project

Project/Area Number 20790957
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKobe University

Principal Investigator

OGATA Satoshi  Kobe University, 医学研究科, 医学研究員 (40444583)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords生体肝移植 / 過小グラフト / 肝静脈再建 / 術後合併症 / 術後肝機能
Research Abstract

The purpose of the present study is to evaluate new criteria for donor selection in living donor liver transplantation(LDLT)of the small-for-size liver graft.
We have tried to grasp the post operational changes of hepatic veins in a three dimensional asepect,and designed a new procedure for hepatic vein reconstruction so as to accommodate the changes.
This not only gives patients who had been formerly considered to be outside the liver transplantation criteria because of the absent of donor with enough graft volume a chance to safely undergo transplantations, but has also implies the possibility of improving the safety of donor, which is the primary importance in LDLT.
Our study has obtained a result of high significance.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 1 results) Presentation (17 results)

  • [Journal Article] Liver hanging maneuver2011

    • Author(s)
      尾形哲、幕内雅敏
    • Journal Title

      手術

      Volume: 65 Pages: 155-158

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 生体ドナーの安全とレシピエントの予後向上をめざして2010

    • Author(s)
      尾形哲、幕内雅敏
    • Journal Title

      肝胆膵画像 12

      Pages: 11-16

    • Related Report
      2010 Final Research Report
  • [Journal Article] 生体肝移植後の胆管合併症の診断と治療2010

    • Author(s)
      辻野武、尾形哲、幕内雅敏
    • Journal Title

      肝胆膵画像 12

      Pages: 79-88

    • Related Report
      2010 Final Research Report
  • [Journal Article] Recovery of Liver Function After the Cessation of Preoperative Chemotherapy for Colorectal Liver Metastasis2010

    • Author(s)
      Takamoto T, Hashimoto T, Sano K, Maruyama Y, Inoue K, Ogata S, Takemura T, Kokudo N, Makuuchi M.
    • Journal Title

      Ann Surg Oncol

    • Related Report
      2010 Final Research Report
  • [Journal Article] 生体ドナーの安全とレシピエントの予後向上をめざして2010

    • Author(s)
      尾形哲、幕内雅敏
    • Journal Title

      肝胆膵画像

      Volume: 12 Pages: 11-16

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 生体肝移植後の胆管合併症の診断と治療2010

    • Author(s)
      辻野武、尾形哲、幕内雅敏
    • Journal Title

      肝胆膵画像

      Volume: 12 Pages: 79-88

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 手術症例報告経皮的肝灌流化学療法にてCRとなった肝移植後両葉多発肝細胞癌の1例2009

    • Author(s)
      木下秘我、尾形哲、具英成
    • Journal Title

      手術 63(4)

      Pages: 531-534

    • NAID

      40016602738

    • Related Report
      2010 Final Research Report
  • [Journal Article] Heat-zone effect after surface application of dissecting sealer on "in situmargin" after tumorectomy for liver tumors2008

    • Author(s)
      Kianmanesh R, Ogata S, et.al.
    • Journal Title

      Journal of American College of Surgery 206(3)

      Pages: 1122-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本外科学会移植2010

    • Author(s)
      幕内雅敏, 尾形哲
    • Organizer
      特別ビデオセッション 生体肝移植の技術革新
    • Related Report
      2010 Final Research Report
  • [Presentation] 国際肝癌シンポジウム神戸2009

    • Author(s)
      Satoshi Ogata, Keiji Sano, Yoshikazu Maruyama, Kazuto Inoue, Takuya Hashimoto, Takeshi Takamato, Yujiro Nishioka, Masatoshi Makuuchi.
    • Organizer
      Pretransplant Splenectomy Initiates Early Antiviral Therapy for Recurrent Hepatitis C after Living Donor Liver Transplantation for Hepatocellular Carcinoma
    • Related Report
      2010 Final Research Report
  • [Presentation] 右3区域切除・肝灌流後に循環障害を来たし、肝移植に至った1例2008

    • Author(s)
      尾形哲、福本巧、富永正寛、岩崎武、楠信也、木戸正浩、高橋応典、具英成
    • Organizer
      近畿肝移植検討会
    • Place of Presentation
      大阪
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] SHOULD WE RETURN TO THE LEFT IN ADULT LIVING DONOR LIVER TRANSPLANTATION?2008

    • Author(s)
      Satoshi Ogata
    • Organizer
      日韓肝移植フォーラム
    • Place of Presentation
      Seoul
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体肝移植前に免疫抑制剤の投与を必要とした急性赤芽球癆合併原発性硬化性胆管炎の1例2008

    • Author(s)
      尾形哲、福本巧、富永正寛、岩崎武、楠信也、木戸正浩、高橋応典、具英成
    • Organizer
      第43回日本移植学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 右葉成人生体肝移植後のグラフト回転による肝静脈の3次元的変化2008

    • Author(s)
      尾形哲、福本巧、富永正寛、岩崎武、楠信也、木戸正浩、高橋応典、具英成
    • Organizer
      肝癌シュミレーション研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 成人生体部分肝移植における移植後のグラフト回転を考慮した新しい肝静脈再建法2008

    • Author(s)
      尾形哲、福本巧、富永正寛、岩崎武、楠信也、木戸正浩、高橋応典、具英成
    • Organizer
      第63回日本消化器外科学会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] SHOULD WE RETURN TO THE LEFT IN ADULT LIVING DONOR LIVER TRANSPLANTATION?2008

    • Author(s)
      Satoshi Ogata
    • Organizer
      THE INTERNATIONAL LIVER TRANSPLANTA TION SOCIETY 14TH ANNUAL INTERNATIONAL CONGRESS
    • Place of Presentation
      PARIS
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 成人生体肝移植後のグラフト回転を考慮した新しい肝静脈再建法2008

    • Author(s)
      尾形哲、福本巧、富永正寛、岩崎武、楠信也、木戸正浩、高橋応典、文宣貴、具英成
    • Organizer
      第26回日本肝移植研究会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 下大静脈直接浸潤肝癌に対するLiver Hanging Maneuverを用いた肝右葉切除術2008

    • Author(s)
      尾形哲、J. Belghiti、富永正寛、岩崎武、福本巧、具英成
    • Organizer
      第108回日本外科学会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 消化器外科学会シンポジウム2008

    • Author(s)
      尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
    • Organizer
      生体肝移植における脈管再建部の合併症成人生体部分肝移植における移植後のグラフト回転を考慮した新しい肝静脈再建法
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本肝移植研究会要望演題2008

    • Author(s)
      尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
    • Organizer
      分枝を含めた肝静脈再建の適応と工夫成人生体肝移植後のグラフト回転を考慮した新しい肝静脈再建法
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本移植学会2008

    • Author(s)
      尾形哲, 福本巧、高橋応典、冨永正寛、岩崎 武、楠信也、木戸正浩、具英成
    • Organizer
      生体肝移植前に免疫抑制剤の投与を必要とした急性赤芽球癆合併原発性硬化性胆管炎の1例
    • Related Report
      2010 Final Research Report
  • [Presentation] 国際肝移植学会2008

    • Author(s)
      Satoshi Ogata, Takumi Fukumoto, Masahiro Tominaga, Takeshi Iwasaki, Nobuya Kusunoki, Masahiro Kido, Yonson Ku.
    • Organizer
      Should we return to the left in adult to adult living donor liver transplantation?
    • Related Report
      2010 Final Research Report
  • [Presentation] 日韓肝移植フォーラム2008

    • Author(s)
      Satoshi Ogata, Takumi Fukumoto, Masahiro Tominaga, Takeshi Iwasaki, Nobuya Kusunoki, Masahiro Kido, Yonson Ku.
    • Organizer
      Should we return to the left in adult to adult living donor liver transplantation?
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝癌治療シミュレーション研究会2008

    • Author(s)
      尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
    • Organizer
      右葉成人生体肝移植後のグラフト回転による肝静脈の3次元的変化
    • Related Report
      2010 Final Research Report
  • [Presentation] 近畿肝移植検討会2008

    • Author(s)
      尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
    • Organizer
      右3区域切除・肝灌流後に循環障害を来たし、肝移植に至った1例
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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