Elucidation of significance of lymphangiogenesis and lymph node micrometastasis in lymphatic metastasis

• Project/Area Number: 20790963
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: KURAHARA Hiroshi Kagoshima University, 医学部・歯学部附属病院, 医員 (70464469)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: リンパ節転移 / 微小転移 / リンパ管新生 / 微小環境 / 腫瘍関連マクロファージ / リンパ節転 / 消化器癌

Research Abstract

Pancreatic cancer induces lymphangiogenesis in the primary tumor and the regional lymph nodes by producing VEGF-C. Dissemination of cancer cells to other organs was promoted through the increased lymphatic vessels. And pancreatic cancer educates macrophages which were recruited to the tumor to help tumor progression. The educated macrophages increase lymphatic vessels in cooperation with the cancer cells, and further facilitate metastasis of cancer cells.

Research Products

• [Journal Article] Significance of M2-polarized tumor-associated macrophage in pancreatic cancer. (2009)
  • Author(s): Hiroshi Kurahara, Hiroyuki Shinchi, Yuko Mataki, Kousei Maemura, Hidetoshi Noma, Fumitake Kubo, Masahiko Sakoda, Shinichi Ueno, Shoji Natsugoe, Sonshin Takao
  • Journal Title: Journal of Surgical Research
  • Peer Reviewed
• [Journal Article] Significance of M2-polarized tumor-associated macrophage in pancreatic cancer (2009)
  • Author(s): Hiroshi Kurahara
  • Journal Title: Journal of Surgical Research (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 膵頭部癌のリンパ行性転移におけるtumor-associated macrophageの意義 (2009)
  • Author(s): 蔵原弘
  • Organizer: 第40回日本膵臓学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-30
• [Presentation] pN0膵頭部癌におけるリンパ行性転移に関する検討 (2009)
  • Author(s): 蔵原弘
  • Organizer: 第39回日本膵臓学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-07-30
• [Presentation] 膵癌の微小環境形成におけるtumor-associated macrophageの意義 (2009)
  • Author(s): 蔵原弘
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-03
• [Presentation] pNO膵頭部癌におけるリンパ行性転移に関する検討 (2008)
  • Author(s): 蔵原弘
  • Organizer: 第39回日本膵癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-07-30
• [Presentation] pN0膵頭部癌におけるリンパ節微小転移に関する検討 (2008)
  • Author(s): 蔵原弘
  • Organizer: 第20回日本肝胆膵外科学会
  • Place of Presentation: 山形
  • Year and Date: 2008-05-29
• [Presentation] pNO膵頭部癌におけるリンパ節微小転移に関する検討 (2008)
  • Author(s): 蔵原弘
  • Organizer: 第20回日本肝胆膵外科学会
  • Place of Presentation: 山形
  • Year and Date: 2008-05-29
• [Presentation] 膵頭部癌のリンパ行性転移におけるリンパ管新生の意義 (2008)
  • Author(s): 蔵原弘
  • Organizer: 第108回日本外科学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-16
• [Presentation] ntratumoral lymphangiogenesis correlates with lymphatic invasion, nodal status, and vascular endothelial growth factor (VEGF)-C in pancreatic cancer. (2008)
  • Author(s): Hiroshi Kurahara
  • Organizer: 8th World Congress IHPBA
  • Place of Presentation: Mumbai
  • Year and Date: 2008-03-01