| Project/Area Number |
20790973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
SAKAMOTO Taro Jikei University School of Medicine, 医学部, 助教 (60366234)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | T-614 / 血管新生 / 肝細胞癌 / 治療 |
|---|
| Research Abstract |
Anti-rheumatic agent T-614 significantly suppressed serum concentration of interleukin-8(IL-8), tumor size, and the number of tumors in the rat hepatocellular carcinoma(HCC) models. In addition, immunohistochemical staining of the rat liver (both normal hepatocytes and HCC cells) using anti-CD31 revealed significant decrease in CD 31 positive cells. Since IL-8 plays an important role in angiogenesis through CD31 molecule, these results suggest that T-614 may contribute as an anti-angiogenic therapy in HCC.
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