Expression and localization of keratinocyte growth factor receptor (KGFR) in esophageal cancer and molecular target thrapy

Research Project

Project/Area Number	20790975
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Nippon Medical School
Principal Investigator	YOSHINO Masanori Nippon Medical School, 医学部, 助教 (10343609)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	食道外科学 / KGFR / KGF / 食道癌 / siRNA / Western Blot / RT-PCR / 免疫組織化学染色 / Ki-67
Research Abstract	The progress of the recent molecular target drug is remarkable, and the medicine associated with the growth factor receptor is applied clinically, and those effectiveness is confirmed. Therefore we thought that we could apply these treatment to even relatively developing esophageal cancer in the field of molecular target therapy and aimed at a role of keratinocyte growth factor receptor (KGFR) which played role that was important to proliferation of cells and angiogenesis in esophageal cancer. Progressed a study whether KGFR was associated with a proliferation of esophageal cancer whether we might prevent growth of esophageal cancer by inhibiting KGFR and examined it about the future as the molecular target therapy.