| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Research Abstract |
Congenital heart disease with high pulmonary flow is frequently complicated by the development of irreversible pulmonary hypertension. Endothelial cell injury by increased shear stress may play a key role to induce intimal and medial hypertrophy and increase vascular resistance. We analyzed the plasma VEGF (vascular endothelial growth factor) in patients with pulmonary hypertension. The plasma VEGF level in pulmonary hypertension was significantly increased compared with control (157.4±35.4pg/ml vs. 43.0±22.9pg/ml, mean±SE). Also we performed the pulmonary angiography in high flow pulmonary hypertension model rat by using synchrotron radiation micro-angiography (SRMA) to measure the pulmonary flow velocity and shear stress. The velocity of proximal pulmonary artery in pulmonary hypertension rat was 111.5±23.5mm/sec and 111.5±23.5mm/sec in control. Although, the velocity of distal pulmonary artery in pulmonary hypertension rat was significantly increased as 71.7±23.2mm/sec compared with control as 9.4±2.6mm/sec. This result suggests that higher pulmonary artery velocity may affect the endothelial cell injury and increase vascular resistance. Further evaluation about endothelial cell injury and VEGF level at the pulmonary tissue will be performed.
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