Effects of omentopexy combined with granulocyte colony-stimulating factor in a rabbit heart model

Research Project

Project/Area Number	20790985
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	Gifu University
Principal Investigator	ISHIDA Narihiro Gifu University, 医学部附属病院, 医員 (90397331)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	G-CSF / 大網充填 / 血管新生 / 心機能
Research Abstract	We investigated whether or not omentopexy combined with granulocyte colony-stimulating factor (G-CSF) subcutaneous administration reduced infarction area and improved left ventricular (LV) dysfunction in a coronary occlusion and reperfusion model. Echocardiography showed improvement of LV dysfunction and infarction/ischemic area ratio was reduced. Omentopexy with G-CSF administration improved LV function and decreased infarction area.