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Role of Toll-like receptor 4 in myocardial ischemic-reperfusion injury

Research Project

Project/Area Number 20790987
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionMie University

Principal Investigator

SHIN Shomura  Mie University, 医学部・附属病院, 医員 (70452224)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords外科 / 移植・再生医療 / シグナル伝達 / 循環器・高血圧
Research Abstract

Ischemic preconditioning is mediated a MyD88-independent pathway, leading to NF-κB activation and protection against myocardial ischemic-reperfusion injury. We conclude that an activation of MyD88 or TRIF, which are associate proteins of Toll-like receptor 4, would regulate a role of NF-κB to injure or protect myocardium.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2009

All Presentation (2 results)

  • [Presentation] MyD88-Independent signaling pathway is involved with myocardial ischemic preconditioning.2009

    • Author(s)
      Shimamoto A, Shomura S, Agnew ML, Rothnie CL, Spring DJ, Shimpo H, Verrier ED.
    • Organizer
      19th World Society of Cardio-Thoracic Surgeons
    • Place of Presentation
      ブエノスアイレス・アルゼンチン
    • Year and Date
      2009-11-06
    • Related Report
      2009 Final Research Report
  • [Presentation] MyD88-Independent signaling Pathway Is Involved with Myocardial Ischemic Preconditioning2009

    • Author(s)
      Shimamoto A
    • Organizer
      19^<th> World Society of Cardio-Thoracic Surgeons
    • Place of Presentation
      ブエノスアイレス・アルゼンチン
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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