Fluorescence diagnosis of lung cancer and malignant mesothelioma using orthotopic ijplamtation SCID mice model
| Project/Area Number |
20790991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKIZAWA Hiromitsu The University of Tokushima, 医学部・歯学部附属病院, 講師 (90332816)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 蛍光診断 / 5-アミノレブリン酸 / タラポルフィン / SCIDマウス / 肺癌 / 悪性胸膜中皮腫 / リンパ節転移 / 光感受性物質 |
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| Research Abstract |
Human lung cancer cell line A549, Ma44-3 and human malignant mesothelioma cell line MST0211H were injected into left lung or left pleural cavity of severe combined immunodeficiency disease mice. The mice were administered 5-aminolevulinic acid or mono-L-aspartyl chlorine e6 1 to 3 weeks after the implantation. The mice were sacrificed several hours after the administration of these drugs. Their chest walls were opened and illuminated with blue light (405nm). Clear red fluorescence was observed in lung tumors, metastatic lymph nodes, and pleural tumors, even though the tumors were invisible macroscopically under white light. This result suggests possibility of clinical application of fluorescence diagnosis with intrapleural malignant tumors.
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Report
(3 results)
Research Products
(3 results)
