| Project/Area Number |
20790993
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
OSHIRO Hisashi Yokohama City University, 附属病院, 助教 (60381513)
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| Research Collaborator |
大谷 修 富山大学, 大学院・医学薬学研究部, 教授 (90127548)
三浦 真弘 大分大学, 医学部, 講師 (50199957)
青葉 孝昭 日本歯科大学, 歯学部, 教授 (30028807)
島津 徳人 日本歯科大学, 歯学部, 講師 (10297947)
工藤 朝雄 日本歯科大学, 歯学部
海老原 善郎 東京医科大学, 医学部, 名誉教授
工藤 玄恵 東京医科大学, 医学部, 教授 (10130361)
芹澤 博美 東京医科大学, 医学部, 准教授
吉濱 勲 東京医科大学, 医学部, 講師
千島 隆司 横浜市立大学, 医学部, 准教授 (70438141)
前川 二郎 横浜市立大学, 医学部, 准教授
長濱 清隆 横浜市立大学, 医学部, 助教 (00336538)
奥寺 康司 横浜市立大学, 医学部, 助教 (10326027)
深澤 由里 東邦大学, 医学部, 助教 (90392331)
SUAMI Hiroo The University of Texas・MD Anderson Cancer Center, Assistant Professor
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺靱帯 / リンパ管小孔 / 癌性胸水 / 胸膜播種 / リンパ行性転移 / 胸管 / 静脈角リンパ節 / Vascular endothelial growth factor (VEGF) / VEGF / 中皮リンパ管小孔 / 転移 / 予後 |
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| Research Abstract |
Autopsy cases with carcinomas were analyzed in order to elucidate mechanisms of cancerous pleural effusion in humans. Chi-square test demonstrated that the frequencies of dissemination/invasion onto the pleura, pulmonary hilar lymph node metastasis, metastasis to the lymphatic stomata on the pulmonary ligament, and venous angle lymph node metastasis in cases with cancerous pleural effusion were all significantly higher than those in cases without cancerous pleural effusion; however, multiple logistic regression analysis demonstrated that among these variables, only the metastasis to the lymphatic stomata on the pulmonary ligament was a significantly independent predictive factor for cancerous pleural effusion. Among untreated cases with cancerous pleural effusion, Ki-67 and apoptosis indexes of cancer cells were not significantly different between primary lesions and metastatic lesions to the lymphatic stomata on the pulmonary ligament; however, VEGF-C immunohistochemistry demonstrated a potentially increased expression levels at the metastatic lesions to the lymphatic stomata compared with the primary lesions, and E-cadherin immunohistochemistry demonstrated a potentially decreased expression levels at the metastatic lesions to the lymphatic stomata compared with the primary lesions. These results raise a possibility that cancer metastasis to the lymphatic stomata plays a role in the pathogenesis of cancerous pleural effusion.
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