Study of optimization of extracorporeal circulation in open heart surgery on diminished immune function

• Project/Area Number: 20790996
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Kitasato University
• Principal Investigator: SHINBO Toshihiro Kitasato University, 医療衛生学部, 助教 (10406910)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 人工心肺 / 体外循環 / リンパ球

Research Abstract

In the present study, to elucidate the effects of extracorporeal circulation in open heart surgery on the immune system, I focused on the function of lymphocytes and examined the changes in the ability of lymphocyte blastoid transformation. After the treatment with Phytohemagglutinin(PHA), ability of lastoid transformation in contact with the extracorporeal circulation circuit with membrane oxygenator was lower than the ability in contact with extracorporeal circulation circuit without membrane oxygenator. There was no significant difference of the ability between the closed extracorporeal circulation circuit and the opened extracorporeal circulation circuit. And there was no significant difference of the ability between the extracorporeal circulation circuit without oxygenator gas and the extracorporeal circulation circuit with oxygenator gas too.