To discover the master regulators of stemness in the bronchiolealveolar stem cells.

• Project/Area Number: 20790998
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: HATO Tai Keio University, 医学部, 助教 (10365281)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 呼吸器外科学 / 呼吸器外科 / 肺の再生 / 肺胞上皮幹細胞 / Angiooietin-1 / Tie2

Research Abstract

Although lung regeneration is observed in infants after major lung resection, same phenomenon is seldom observed in adults in human beings. We sought to identify the master regulator of lung regeneration. We put our focus on bronchioloalvelolar stem cells (BASCs). Using lung post pneumonectomy compensatory lung growth model, we compared mRNA expression profiles of the BASCs through PCR array technology.

Research Products

• [Journal Article] Angiopoietins contribute to lung development by regulating pulmonary vascular network formation (2009)
  • Author(s): Hato T, Kimura Y, Morisada T, Koh GY, Miyata K, Tabata M, Kadomatsu T, Endo M, Urano T, Arai F, Araki K, Suda T, Kobayashi K, Oike Y.
  • Journal Title: Biochem Biophys Res Commun 381(2) Pages: 218-223
  • Peer Reviewed
• [Journal Article] Angiopoietins contribute to lung development by regulating pulmonary vascular network formation (2009)
  • Author(s): Hato T, Kimura Y, Morisada T, et.al.
  • Journal Title: Biochem. Biophys. Res. Comm. (In press)
  • Peer Reviewed
• [Journal Article] Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model (2008)
  • Author(s): Urano T, Ito Y, Hato T, et.al.
  • Journal Title: Arterioscler Thromb Vasc Biol 28(5) Pages: 827-834
  • Peer Reviewed
• [Presentation] 中葉原発肺がんは予後不良か当院での肺癌中葉切除症例の再考 (2009)
  • Author(s): 羽藤泰、原田匡彦、堀尾裕俊
  • Organizer: 第50回日本肺癌学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-12
• [Presentation] Angiopoietin-1は肺血管網形成を制御して肺発生に寄与する (2009)
  • Author(s): 羽藤泰、木村吉成、小林紘一、野守裕明
  • Organizer: 第62回胸部外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-12
• [Presentation] 多発嚢胞と濾胞性リンパ球増殖を伴った胸腺過形成の1例 (2009)
  • Author(s): 羽藤泰、原田匡彦、堀尾裕俊
  • Organizer: 第154回日本肺癌学会関東支部会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-14
• [Presentation] Ectopic expression of Angiopoietin-1 in lung epithelium disrupted lung alveolarization (2008)
  • Author(s): Hato T
  • Organizer: American Thoracic Society
  • Place of Presentation: Tronto
  • Year and Date: 2008-05-19
• [Presentation] Ectopic expression of Angiopoietin-1 in lung epithelium disrupted lung alveolarization (2008)
  • Author(s): Tai Hato
  • Organizer: American Thoracic Society
  • Place of Presentation: トロント
  • Year and Date: 2008-05-19
• [Presentation] 肺乳頭状腺腫(papillary adenoma)の1例 (2008)
  • Author(s): 羽藤泰、川久保雅祥, 山内良兼, 福冨寿典, 井澤菜緒子, 木村吉成, 河野光智, 泉陽太郎, 渡辺真純, 堀之内宏久, 川村雅文, 林雄一郎
  • Organizer: 第26回日本呼吸器外科学会総会
  • Place of Presentation: 小倉
  • Year and Date: 2008-05-14
• [Book] 【呼吸器症候群(第2版)その他の呼吸器疾患を含めて】腫瘍性疾患その他腫瘍性病変 嚢腫日本臨床(0047-1852)別冊呼吸器症候群III (2009)
  • Author(s): 羽藤泰、小林紘一
• [Book] 【目でみる診療基本手技】診療手技チューブ挿入法・カテーテル管理法チェストチューブの入れ方と管理(脱気法を含む) (2008)
  • Author(s): 羽藤泰、川村雅文
  • Publisher: Medicina