Development of human lung cancer model using NOD/SCID/γC null mouse

• Project/Area Number: 20790999
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Tokai University
• Principal Investigator: INOUE Yoshimasa Tokai University, 医学部, 講師 (30306716)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: NOG mouse / MRI (magnetic resonace imageing) / 非小細胞肺癌 / NOGマウス / MRI / 正所性移植モデル / Comuted tomograhy(CT)

Research Abstract

We studied a noninvasive method to evaluate tumor growth in the lung of mice. Xenotransplant model of lung cancer (NSCLC) using NOD/SCID/γcnull (NOG) mice was developed by tail vain injection of human lung cancer cell line (A549). The lung consolidation detected by MRI (magnetic resonace imageing) deteriorated in parallel with intrapulmonary tumor growth. MRI may be useful to noninvasively evaluate tumor growth in lung of mice.