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Protective Actions of Adiponectin on Cerebral Ischemia-reperfusion Injury.

Research Project

Project/Area Number 20791008
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKyoto University

Principal Investigator

NISHIMURA Masaki  Kyoto University, 医学研究科, 助教 (60452348)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳卒中 / 肥満 / 脳血流 / 脳梗塞 / アディポネクチン / 脳・神経 / 循環器
Research Abstract

Adiponectin is a fat-derived plasma protein that has beneficial actions on cardiovascular disorders. Low level of plasma adiponectin is associated with increased mortality following ischemic stroke. However, the causal role of adiponectin in ischemic stroke is unknown. APN-KO mice exhibited enlarged brain infarction and increased neurological deficits following ischemia-reperfusion compared with WT mice. Conversely, adenovirus-mediated supplementation of adiponectin significantly reduced cerebral infarct size in WT and APN-KO mice. APN-KO mice showed decreased cerebral blood flow during ischemia by laser speckle flowmetry methods. These data provide a novel evidence that adiponectin exerts a cerebroprotective action. Adiponectin could represent a molecular target for the prevention of ischemic stroke

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms.2008

    • Author(s)
      Nishimura M, Ouchi N., et. al.
    • Journal Title

      Circulation 117(2)

      Pages: 216-223

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Protective Actions of Adiponectin on Cerebral Ischemia-reperfusion Injury.2008

    • Author(s)
      西村真樹, 他
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-10-02
    • Related Report
      2009 Final Research Report
  • [Presentation] アディポネクチンの脳虚血保護作用の解析2008

    • Author(s)
      西村真樹
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] アディポネクチンの急性期脳虚血保護作用の解析2008

    • Author(s)
      西村真樹, 他
    • Organizer
      第33回日本脳卒中学会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-21
    • Related Report
      2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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