Plaque visualization and hemodynamic analysis with magnetic resonance imaging in swine carotid atherosclerosis model
| Project/Area Number |
20791009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
ISHII Akira Kyoto University, 医学研究科, 助教 (30467469)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MRI / 不安定プラーク / 頚動脈狭窄症 / 頚動脈 / 壁面せん断応力 / 近赤外線 |
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| Research Abstract |
The purpose of the present study is to elucidate the role of hemodynamics in atherosclerosis by experimental induction of atherosclerotic plaque in the swine carotid artery. Complex atherosclerotic plaque was successfully induced in the lesion distal to surgical partial ligation. Systolic and diastolic flow velocity were obtained with phase contrast sequence in 3.0 Tesla MRI. Wall shear stress was calculated with the obtained dataset. Shear stress was maintained high in the lesion distal to surgical partial ligation due to unidirectional jet flow. By contrast, in the lesion proximal to ligation, shear stress was found to oscillate during cardiac cycle. Low wall shear stress may contribute to plaque formation in this animal model.
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Report
(4 results)
Research Products
(8 results)
