Combined therapy of MSC transplantation and rehabilitation for Disuse syndrome
| Project/Area Number |
20791011
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
YASUHARA Takao Okayama University, 岡山大学病院, 助教 (50457214)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳血管障害学 / 脳卒中 / 細胞療法 / 神経新生 / 寝たきり / 頭部外傷 / リハビリテーション / 骨髄幹細胞 / ラット / 廃用萎縮 / 神経幹細胞 / 細胞移植 |
|---|
| Research Abstract |
Surviving rates of transplanted mesenchymal stem cells (MSCs) significantly increased by rehabilitation in normal rats, disuse syndrome model of rats, traumatic brain injury model of rats and Parkinson's disease model of rats. In disuse syndrome model of rats and traumatic brain injury model of rats, rehabilitation significantly ameliorated behavioral scores. Additionally, transplanted MSCs are broadly found in the cerebrum with significant neuronal differentiation in disuse syndrome model of rats, Parkinson's disease model of rats. Rehabilitation also enhanced the expression of neurotrophic factors.
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Report
(3 results)
Research Products
(168 results)
