| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Recent studies have begun to draw attention to neurogenesis in various brain regions other than the hippocampus and subventricular zone of the forebrain. These include several reports of adult neurogenesis in the cortex. Our results provide direct evidence that Olig2 progenitors with proliferative potential exist in adult cortex and that they preferentially differentiate into astrocytes in response to injury. Our study raises the possibility that Olig2 progenitors, which are, at least in part, the origin of astrocytes in glial scars, would be a target for potential therapeutic interventions after CNS injury.
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