| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
Hyperthermia decreased motility of osteosarcoma cells via suppression of autocrine motility factor expression, while did not affect mineralization of osteosarcoma cells. Microarray revealed some subtypes of bone morphogenic protein (BMP) decreased by hyperthermia although others increased, that may compensate bone formation.
AMF is known to be identical to phosphoglucose isomerase that is an essential protein for glycolysis. We revealed metastatic tumor showed higher glucose than primary tumor did, that is compatible with the fact that AMF stimulates tumor motility and metastasis.
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